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Literature DB >> 7447705

Rimantadine hydrochloride blocks the second step of influenza virus uncoating.

A G Bukrinskaya, N K Vorkunova, R A Narmanbetova.

Abstract

Two steps of influenza virus A/WSN uncoating in MDCK cells are described. The products of the first step are cores which accumulate in the nuclear-associated cytoplasm. The products of the second step are ribonucleoproteins which penetrate the nuclei. Rimantadine blocks the second step without interfering with the first one.

Entities: Chemical Species

Mesh：

Substances：

Year: 1980 PMID： 7447705 DOI： 10.1007/bf01314742

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

6 in total

1. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

2. Cytoplasmic and nuclear input virus RNPs in influenza virus-infected cells.

Authors: A G Bukrinskaya; G K Vorkunova; N K Vorkunova
Journal: J Gen Virol Date: 1979-12 Impact factor: 3.891

3. Susceptibility of influenza A viruses to amantadine is influenced by the gene coding for M protein.

Authors: M D Lubeck; J L Schulman; P Palese
Journal: J Virol Date: 1978-12 Impact factor: 5.103

4. The matrix protein gene determines amantadine-sensitivity of influenza viruses.

Authors: A J Hay; N C Kennedy; J J Skehel; G Appleyard
Journal: J Gen Virol Date: 1979-01 Impact factor: 3.891

5. On the mechanism of inhibition of influenza virus replication by amantadine hydrochloride.

Authors: J J Skehel; A J Hay; J A Armstrong
Journal: J Gen Virol Date: 1978-01 Impact factor: 3.891

6. Inhibition of influenza virus uncoating by rimantadine hydrochloride.

Authors: W C Koff; V Knight
Journal: J Virol Date: 1979-07 Impact factor: 5.103

6 in total

7 in total

Review 1. Antiviral therapy: current concepts and practices.

Authors: B Bean
Journal: Clin Microbiol Rev Date: 1992-04 Impact factor: 26.132

2. Neutralization of influenza virus by low concentrations of hemagglutinin-specific polymeric immunoglobulin A inhibits viral fusion activity, but activation of the ribonucleoprotein is also inhibited.

Authors: S J Armstrong; N J Dimmock
Journal: J Virol Date: 1992-06 Impact factor: 5.103

Rimantadine hydrochloride blocks the second step of influenza virus uncoating.

1. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

2. Cytoplasmic and nuclear input virus RNPs in influenza virus-infected cells.

3. Susceptibility of influenza A viruses to amantadine is influenced by the gene coding for M protein.

4. The matrix protein gene determines amantadine-sensitivity of influenza viruses.

5. On the mechanism of inhibition of influenza virus replication by amantadine hydrochloride.

6. Inhibition of influenza virus uncoating by rimantadine hydrochloride.

Review 1. Antiviral therapy: current concepts and practices.

2. Neutralization of influenza virus by low concentrations of hemagglutinin-specific polymeric immunoglobulin A inhibits viral fusion activity, but activation of the ribonucleoprotein is also inhibited.

3. Current status of amantadine and rimantadine as anti-influenza-A agents: memorandum from a WHO meeting.

4. Novel treatment with neuroprotective and antiviral properties against a neuroinvasive human respiratory virus.

Review 5. Early interactions between animal viruses and the host cell: relevance to viral vaccines.

Review 6. Potential for the Repurposing of Adamantane Antivirals for COVID-19.

7. Chapter 7 Orthomyxovirus infections.