Literature DB >> 7592022

The ripostatins, novel inhibitors of eubacterial RNA polymerase isolated from myxobacteria.

H Irschik1, H Augustiniak, K Gerth, G Höfle, H Reichenbach.   

Abstract

A new antibiotic, ripostatin, was isolated from the culture supernatant of the myxobacterium, sorangium cellulosum strain So ce377. It is a macrocyclic lactone carbonic acid containing an unsubstituted phenyl ring in a side chain. The antibiotic acts especially on Staphylococcus aureus, but seems not to penetrate most bacteria. The MIC values are in the range of 1 microgram/ml. Ripostatin is an inhibitor of eubacterial RNA polymerase. It interferes with the initiation of RNA synthesis.

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Year:  1995        PMID： 7592022     DOI： 10.7164/antibiotics.48.787

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  14 in total

1.  RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus.

Authors:  A O'Neill; B Oliva; C Storey; A Hoyle; C Fishwick; I Chopra
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

Review 2.  Bacterial Transcription as a Target for Antibacterial Drug Development.

Authors:  Cong Ma; Xiao Yang; Peter J Lewis
Journal:  Microbiol Mol Biol Rev       Date:  2016-01-13       Impact factor: 11.056

3.  Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.

Authors:  Sonia I Maffioli; Yu Zhang; David Degen; Thomas Carzaniga; Giancarlo Del Gatto; Stefania Serina; Paolo Monciardini; Carlo Mazzetti; Paola Guglierame; Gianpaolo Candiani; Alina Iulia Chiriac; Giuseppe Facchetti; Petra Kaltofen; Hans-Georg Sahl; Gianni Dehò; Stefano Donadio; Richard H Ebright
Journal:  Cell       Date:  2017-06-15       Impact factor: 41.582

4.  Chemoselective reductive cross-coupling of 1,5-diene-3-ols with alkynes: a facile entry to stereodefined skipped trienes.

Authors:  Peter S Diez; Glenn C Micalizio
Journal:  J Am Chem Soc       Date:  2010-07-21       Impact factor: 15.419

5.  Affinity Selection-Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor.

Authors:  Scott S Walker; David Degen; Elliott Nickbarg; Donna Carr; Aileen Soriano; Mihir Mandal; Ronald E Painter; Payal Sheth; Li Xiao; Xinwei Sher; Nicholas Murgolo; Jing Su; David B Olsen; Richard H Ebright; Katherine Young
Journal:  ACS Chem Biol       Date:  2017-03-31       Impact factor: 5.100

6.  Marine myxobacteria as a source of antibiotics--comparison of physiology, polyketide-type genes and antibiotic production of three new isolates of Enhygromyxa salina.

Authors:  Till F Schäberle; Emilie Goralski; Edith Neu; Ozlem Erol; Georg Hölzl; Peter Dörmann; Gabriele Bierbaum; Gabriele M König
Journal:  Mar Drugs       Date:  2010-09-03       Impact factor: 5.118

7.  Convergent and stereospecific synthesis of complex skipped polyenes and polyunsaturated fatty acids.

Authors:  Todd K Macklin; Glenn C Micalizio
Journal:  Nat Chem       Date:  2010-05-23       Impact factor: 24.427

8.  Palladium-catalyzed 1,4-difunctionalization of butadiene to form skipped polyenes.

Authors:  Matthew S McCammant; Longyan Liao; Matthew S Sigman
Journal:  J Am Chem Soc       Date:  2013-03-12       Impact factor: 15.419

Review 9.  New target for inhibition of bacterial RNA polymerase: 'switch region'.

Authors:  Aashish Srivastava; Meliza Talaue; Shuang Liu; David Degen; Richard Y Ebright; Elena Sineva; Anirban Chakraborty; Sergey Y Druzhinin; Sujoy Chatterjee; Jayanta Mukhopadhyay; Yon W Ebright; Alex Zozula; Juan Shen; Sonali Sengupta; Rui Rong Niedfeldt; Cai Xin; Takushi Kaneko; Herbert Irschik; Rolf Jansen; Stefano Donadio; Nancy Connell; Richard H Ebright
Journal:  Curr Opin Microbiol       Date:  2011-08-19       Impact factor: 7.934

10.  The RNA polymerase "switch region" is a target for inhibitors.

Authors:  Jayanta Mukhopadhyay; Kalyan Das; Sajida Ismail; David Koppstein; Minyoung Jang; Brian Hudson; Stefan Sarafianos; Steven Tuske; Jay Patel; Rolf Jansen; Herbert Irschik; Eddy Arnold; Richard H Ebright
Journal:  Cell       Date:  2008-10-17       Impact factor: 41.582
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