Literature DB >> 20586460

Chemoselective reductive cross-coupling of 1,5-diene-3-ols with alkynes: a facile entry to stereodefined skipped trienes.

Peter S Diez1, Glenn C Micalizio.   

Abstract

A convergent synthesis of highly substituted and stereodefined skipped polyenes is described from the reductive cross-coupling of substituted 1,5-diene-3-ols with alkynes. The control of site selectivity in functionalization of the substituted diene is a central feature of this complex fragment union reaction.

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Year:  2010        PMID： 20586460      PMCID： PMC2912438          DOI： 10.1021/ja103836h

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  15 in total

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