| Literature DB >> 7581452 |
R E Straub1, C J MacLean, F A O'Neill, J Burke, B Murphy, F Duke, R Shinkwin, B T Webb, J Zhang, D Walsh.
Abstract
In 265 Irish pedigrees, with linkage analysis we find evidence for a vulnerability locus for schizophrenia in region 6p24-22. The greatest lod score, assuming locus heterogeneity, is 3.51 (P = 0.0002) with D6S296. Another test, the C test, also supported linkage, the strongest results being obtained with D6S296 (P = 0.00001), D6S274 (P = 0.004) and D6S285 (P = 0.006). Non-parametric analysis yielded suggestive, but substantially weaker, findings. This locus appears to influence the vulnerability to schizophrenia in roughly 15 to 30% of our pedigrees. Evidence for linkage was maximal using an intermediate phenotypic definition and declined when this definition was narrowed or was broadened to include other psychiatric disorders.Entities:
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Year: 1995 PMID： 7581452 DOI： 10.1038/ng1195-287
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330