Literature DB >> 11122901

The genetics of schizophrenia.

M T Tsuang1, W S Stone, S V Faraone.   

Abstract

Behavioral genetic studies provide overwhelming evidence that genes contribute to schizophrenia. Recently, genetic studies have provided promising evidence that schizophrenia genes are linked to several chromosomal locations in affected family members. Despite this progress, individual genes for schizophrenia have yet to be identified. Future progress will depend, in part, on the selection of phenotypes that best reflect effects of etiologic genes. One such phenotype is schizotaxia, a clinically meaningful syndrome that reflects the genetic liability to schizophrenia in nonpsychotic individuals. The potential importance of schizotaxia, or similar concepts, for use in genetic studies, is discussed.

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Year:  1999        PMID： 11122901     DOI： 10.1007/s11920-999-0006-0

Source DB:  PubMed          Journal:  Curr Psychiatry Rep        ISSN： 1523-3812            Impact factor:   5.285


  35 in total

1.  Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22.

Authors:  S Wang; C E Sun; C A Walczak; J S Ziegle; B R Kipps; L R Goldin; S R Diehl
Journal:  Nat Genet       Date:  1995-05       Impact factor: 38.330

2.  A schizophrenia locus may be located in region 10p15-p11.

Authors:  R E Straub; C J MacLean; R B Martin; Y Ma; M V Myakishev; C Harris-Kerr; B T Webb; F A O'Neill; D Walsh; K S Kendler
Journal:  Am J Med Genet       Date:  1998-07-10

3.  Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium.

Authors:  S V Faraone; T Matise; D Svrakic; J Pepple; D Malaspina; B Suarez; C Hampe; C T Zambuto; K Schmitt; J Meyer; P Markel; H Lee; J Harkavy Friedman; C Kaufmann; C R Cloninger; M T Tsuang
Journal:  Am J Med Genet       Date:  1998-07-10

4.  Localization of a susceptibility locus for schizophrenia on chromosome 5.

Authors:  R Sherrington; J Brynjolfsson; H Petursson; M Potter; K Dudleston; B Barraclough; J Wasmuth; M Dobbs; H Gurling
Journal:  Nature       Date:  1988-11-10       Impact factor: 49.962

5.  Clinical neuroscience and epidemiology in schizophrenia.

Authors:  L J Seidman
Journal:  Harv Rev Psychiatry       Date:  1997 Mar-Apr       Impact factor: 3.732

Review 6.  Genetically mediated vulnerability to schizophrenia.

Authors:  C A Prescott; I I Gottesman
Journal:  Psychiatr Clin North Am       Date:  1993-06

7.  Analysis of chromosome 22 markers in nine schizophrenia pedigrees.

Authors:  H Coon; J Holik; M Hoff; F Reimherr; P Wender; M Myles-Worsley; M Waldo; R Freedman; W Byerley
Journal:  Am J Med Genet       Date:  1994-03-15

8.  Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease.

Authors:  V Arolt; R Lencer; A Nolte; B Müller-Myhsok; S Purmann; M Schürmann; J Leutelt; M Pinnow; E Schwinger
Journal:  Am J Med Genet       Date:  1996-11-22

9.  Mental illness in the biological and adoptive relatives of schizophrenic adoptees. Replication of the Copenhagen Study in the rest of Denmark.

Authors:  S S Kety; P H Wender; B Jacobsen; L J Ingraham; L Jansson; B Faber; D K Kinney
Journal:  Arch Gen Psychiatry       Date:  1994-06

10.  Linkage studies on chromosome 22 in familial schizophrenia.

Authors:  H P Vallada; M Gill; P Sham; L C Lim; S Nanko; P Asherson; R M Murray; P McGuffin; M Owen; D Collier
Journal:  Am J Med Genet       Date:  1995-04-24
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  3 in total

1.  fMRI responses to emotional faces in children and adolescents at genetic risk for psychiatric illness share some of the features of depression.

Authors:  Tracy Barbour; Patrick Pruitt; Vaibhav A Diwadkar
Journal:  J Affect Disord       Date:  2012-01-04       Impact factor: 4.839

Review 2.  Target identification for CNS diseases by transcriptional profiling.

Authors:  C Anthony Altar; Marquis P Vawter; Stephen D Ginsberg
Journal:  Neuropsychopharmacology       Date:  2008-10-15       Impact factor: 7.853

3.  Antioxidant defense system and family environment in adolescents with family history of psychosis.

Authors:  Ana Gonzalez-Pinto; Monica Martinez-Cengotitabengoa; Celso Arango; Immaculada Baeza; Soraya Otero-Cuesta; Montserrat Graell-Berna; César Soutullo; Juan Carlos Leza; Juan Antonio Micó
Journal:  BMC Psychiatry       Date:  2012-11-16       Impact factor: 3.630
  3 in total

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