OBJECTIVE: To outline new insights into the genetic etiology of schizophrenia. METHODS: We discuss several commonly held beliefs about the genetic issues in schizophrenia. RESULTS: The complex genetic nature of the illness poses a challenge for investigators seeking causative genetic mutations. Multiple independent research findings are, however converging to identify a relatively small number of chromosomal locations that appear to contain schizophrenia susceptibility genes. Also, a clinically relevant genetic subtype of schizophrenia (22qDS) has been identified. We are developing a better understanding of how schizophrenia relates to other psychiatric disorders. While investigations into the possible roles of dopaminergic and serotonergic systems continue, other approaches that do not require theories of the mechanism of illness are also being used to identify candidate susceptibility genes. CONCLUSIONS: Research to date suggests that our understanding of the pathophysiology of schizophrenia will soon be fundamentally altered by genetic approaches to this complex disease.
OBJECTIVE: To outline new insights into the genetic etiology of schizophrenia. METHODS: We discuss several commonly held beliefs about the genetic issues in schizophrenia. RESULTS: The complex genetic nature of the illness poses a challenge for investigators seeking causative genetic mutations. Multiple independent research findings are, however converging to identify a relatively small number of chromosomal locations that appear to contain schizophrenia susceptibility genes. Also, a clinically relevant genetic subtype of schizophrenia (22qDS) has been identified. We are developing a better understanding of how schizophrenia relates to other psychiatric disorders. While investigations into the possible roles of dopaminergic and serotonergic systems continue, other approaches that do not require theories of the mechanism of illness are also being used to identify candidate susceptibility genes. CONCLUSIONS: Research to date suggests that our understanding of the pathophysiology of schizophrenia will soon be fundamentally altered by genetic approaches to this complex disease.
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Authors: A G Cardno; E J Marshall; B Coid; A M Macdonald; T R Ribchester; N J Davies; P Venturi; L A Jones; S W Lewis; P C Sham; I I Gottesman; A E Farmer; P McGuffin; A M Reveley; R M Murray Journal: Arch Gen Psychiatry Date: 1999-02
Authors: S D Detera-Wadleigh; J A Badner; W H Berrettini; T Yoshikawa; L R Goldin; G Turner; D Y Rollins; T Moses; A R Sanders; J D Karkera; L E Esterling; J Zeng; T N Ferraro; J J Guroff; D Kazuba; M E Maxwell; J I Nurnberger; E S Gershon Journal: Proc Natl Acad Sci U S A Date: 1999-05-11 Impact factor: 11.205
Authors: S H Shaw; M Kelly; A B Smith; G Shields; P J Hopkins; J Loftus; S H Laval; A Vita; M De Hert; L R Cardon; T J Crow; R Sherrington; L E DeLisi Journal: Am J Med Genet Date: 1998-09-07
Authors: N M Williams; M I Rees; P Holmans; N Norton; A G Cardno; L A Jones; K C Murphy; R D Sanders; G McCarthy; M Y Gray; I Fenton; P McGuffin; M J Owen Journal: Hum Mol Genet Date: 1999-09 Impact factor: 6.150
Authors: Anne S Bassett; Gregory Costain; Wai Lun Alan Fung; Kathryn J Russell; Laura Pierce; Ronak Kapadia; Ronald F Carter; Eva W C Chow; Pamela J Forsythe Journal: J Psychiatr Res Date: 2010-11 Impact factor: 4.791
Authors: Gregory Costain; Mary Jane Esplen; Brenda Toner; Kathleen A Hodgkinson; Anne S Bassett Journal: Schizophr Bull Date: 2012-10-27 Impact factor: 9.306
Authors: Gregory Costain; Mary Jane Esplen; Brenda Toner; Stephen W Scherer; Wendy S Meschino; Kathleen A Hodgkinson; Anne S Bassett Journal: Schizophr Bull Date: 2012-12-12 Impact factor: 9.306
Authors: Linda M Brzustowicz; Jaime Simone; Paria Mohseni; Jared E Hayter; Kathleen A Hodgkinson; Eva W C Chow; Anne S Bassett Journal: Am J Hum Genet Date: 2004-04-02 Impact factor: 11.025