Literature DB >> 7574479

DNA polymerase III holoenzyme: structure and function of a chromosomal replicating machine.

Z Kelman1, M O'Donnell.   

Abstract

DNA polymerase III holoenzyme contains two DNA polymerases embedded in a particle with 9 other subunits. This multisubunit DNA polymerase is the Eschericia coli chromosomal replicase, and it has several special features that distinguish it as a replicating machine. For example, one of its subunits is a circular protein that slides along DNA while clamping the rest of the machinery to the template. Other subunits act together as a matchmaker to assemble the ring onto DNA. Overall, E. coli DNA polymerase III holoenzyme is very similar in both structure and function to the chromosomal replicases of eukaryotes, from yeast all the way up to humans. This review summarizes our present knowledge about the function of the 10 subunits of this replicating machine and how they coordinate their actions for smooth duplication of chromosomes.

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Year:  1995        PMID： 7574479     DOI： 10.1146/annurev.bi.64.070195.001131

Source DB:  PubMed          Journal:  Annu Rev Biochem        ISSN： 0066-4154            Impact factor:   23.643


  131 in total

1.  Impairment of lagging strand synthesis triggers the formation of a RuvABC substrate at replication forks.

Authors:  M J Flores; H Bierne; S D Ehrlich; B Michel
Journal:  EMBO J       Date:  2001-02-01       Impact factor: 11.598

2.  The C-terminal domain of dnaQ contains the polymerase binding site.

Authors:  S A Taft-Benz; R M Schaaper
Journal:  J Bacteriol       Date:  1999-05       Impact factor: 3.490

3.  Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius.

Authors:  K P Hopfner; A Eichinger; R A Engh; F Laue; W Ankenbauer; R Huber; B Angerer
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

4.  Role of the dinB gene product in spontaneous mutation in Escherichia coli with an impaired replicative polymerase.

Authors:  B S Strauss; R Roberts; L Francis; P Pouryazdanparast
Journal:  J Bacteriol       Date:  2000-12       Impact factor: 3.490

5.  Replication-dependent recruitment of the beta-subunit of DNA polymerase III from cytosolic spaces to replication forks in Escherichia coli.

Authors:  Toshinari Onogi; Katsufumi Ohsumi; Tsutomu Katayama; Sota Hiraga
Journal:  J Bacteriol       Date:  2002-02       Impact factor: 3.490

Review 6.  Rescue of arrested replication forks by homologous recombination.

Authors:  B Michel; M J Flores; E Viguera; G Grompone; M Seigneur; V Bidnenko
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

Review 7.  Interaction of the beta sliding clamp with MutS, ligase, and DNA polymerase I.

Authors:  F J López de Saro; M O'Donnell
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

Review 8.  Managing DNA polymerases: coordinating DNA replication, DNA repair, and DNA recombination.

Authors:  M D Sutton; G C Walker
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

9.  PSI-BLAST searches using hidden markov models of structural repeats: prediction of an unusual sliding DNA clamp and of beta-propellers in UV-damaged DNA-binding protein.

Authors:  A F Neuwald; A Poleksic
Journal:  Nucleic Acids Res       Date:  2000-09-15       Impact factor: 16.971

10.  On the specificity of interaction between the Saccharomyces cerevisiae clamp loader replication factor C and primed DNA templates during DNA replication.

Authors:  Manju M Hingorani; Maria Magdalena Coman
Journal:  J Biol Chem       Date:  2002-10-04       Impact factor: 5.157
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