| Literature DB >> 7568060 |
T Saga1, R D Neumann, T Heya, J Sato, S Kinuya, N Le, C H Paik, J N Weinstein.
Abstract
Monoclonal antibodies penetrate bulky tumors poorly after intravenous administration, in part because of specific binding to the target antigen. Experiments presented here demonstrate an analogous phenomenon in micrometastases; poor antibody penetration, attributable to a "binding-site barrier" phenomenon, can be seen in guinea pig micrometastases as small as 300 microns in diameter. Increasing the dose of antibody can partially overcome this limitation, but at a cost in specificity.Entities:
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Year: 1995 PMID： 7568060 PMCID： PMC41095 DOI： 10.1073/pnas.92.19.8999
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205