Literature DB >> 7562948

Synthesis and antimalarial activities of several fluorinated artemisinin derivatives.

Y M Pu1, D S Torok, H Ziffer, X Q Pan, S R Meshnick.   

Abstract

The carbonyl groups in several artemisinin derivatives were converted into geminal difluorinated compounds on treatment with diethylaminosulfur trifluoride. A number of other mono- and polyfluorinated artemisinin derivatives were prepared. Their in vitro antimalarial activities were all equal to or greater than the nonfluorinated analogs or precursors.

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Year:  1995        PMID： 7562948     DOI： 10.1021/jm00020a028

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  4 in total

1.  Comparative molecular field analysis of artemisinin derivatives: ab initio versus semiempirical optimized structures.

Authors:  S Tonmunphean; S Kokpol; V Parasuk; P Wolschann; R H Winger; K R Liedl; B M Rode
Journal:  J Comput Aided Mol Des       Date:  1998-07       Impact factor: 3.686

2.  Comparison of 3D quantitative structure-activity relationship methods: analysis of the in vitro antimalarial activity of 154 artemisinin analogues by hypothetical active-site lattice and comparative molecular field analysis.

Authors:  J R Woolfrey; M A Avery; A M Doweyko
Journal:  J Comput Aided Mol Des       Date:  1998-03       Impact factor: 3.686

Review 3.  Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy.

Authors:  S R Meshnick; T E Taylor; S Kamchonwongpaisan
Journal:  Microbiol Rev       Date:  1996-06

4.  5-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-Trimethyl-perhydro-3,12-ep-oxy-1,2-dioxepino[4,3-i]isochromen-10-yl]oxymeth-yl}benzene-1,3-diol.

Authors:  Waseem Gul; Paulo Carvalho; Ahmed Galal; Mitchell A Avery; Mahmoud A El Sohly
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-01-23
  4 in total

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