Literature DB >> 7519827

Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization.

M R Speicher1, B Schoell, S du Manoir, E Schröck, T Ried, T Cremer, S Störkel, A Kovacs, G Kovacs.   

Abstract

We analyzed 19 chromophobe renal cell carcinomas by means of comparative genomic hybridization. Two tumors revealed no numerical abnormalities. In the remaining 17 cases we found loss of entire chromosomes with underrepresentation of chromosome 1 occurring in all 17 cases; loss of chromosomes 2, 10, and 13 in 16 cases; loss of chromosomes 6 and 21 in 15 tumors; and loss of chromosome 17 in 13 cases. The loss of the Y chromosome was observed in 6 of 13 tumors from male patients, whereas 1 X chromosome was lost in 3 of 4 tumors obtained from females. Comparative genomic hybridization results were verified by interphase cytogenetics. We conclude that a specific combination of multiple chromosomal losses characterizes chromophobe renal cell carcinomas and may help to differentiate them unequivocally from other types of kidney cancer.

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Year:  1994        PMID： 7519827      PMCID： PMC1887405     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


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5.  Histopathologic subtype-specific genomic profiles of renal cell carcinomas identified by high-resolution whole-genome single nucleotide polymorphism array analysis.

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Journal:  Genes Chromosomes Cancer       Date:  2017-07-24       Impact factor: 5.006

7.  Chromophobe renal cell carcinoma with microcystic and adenomatous arrangement and pigmentation--a diagnostic pitfall. Morphological, immunohistochemical, ultrastructural and molecular genetic report of 20 cases.

Authors:  O Hes; T Vanecek; D M Perez-Montiel; I Alvarado Cabrero; M Hora; S Suster; J Lamovec; R Curik; V Mandys; M Michal
Journal:  Virchows Arch       Date:  2005-03-09       Impact factor: 4.064

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Authors:  Maria V Yusenko; Thomas Ruppert; Gyula Kovacs
Journal:  Int J Biol Sci       Date:  2010-04-23       Impact factor: 6.580

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Authors:  Maria V Yusenko; Roland P Kuiper; Tamas Boethe; Börje Ljungberg; Ad Geurts van Kessel; Gyula Kovacs
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10.  Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours.

Authors:  Maria V Yusenko; Dmitry Zubakov; Gyula Kovacs
Journal:  Int J Biol Sci       Date:  2009-07-29       Impact factor: 6.580
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