Literature DB >> 7511406

Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease.

S Y Anandappa1, J H Winstanley, S Leinster, B Green, P S Rudland, R Barraclough.   

Abstract

The messenger RNAs for the angiogenic acidic and basic fibroblast growth factors are expressed at a significantly higher level in samples of human benign neoplastic and hyperplastic tissue than in samples from breast cancers. However, approximately one in four malignant breast cancer samples contain basic fibroblast growth factor mRNA at the same level as in the benign lesions when basic fibroblast growth factor mRNA levels are corrected with respect to levels of expression of glyceraldehyde-3-phosphate dehydrogenase mRNA. A similar proportion of human malignant breast cancer cell lines express a high level of basic fibroblast growth factor mRNA. The results suggest that some malignant breast cancers and their constitutive carcinoma cells express abundant levels of basic fibroblast growth factor mRNA. The resultant production of basic fibroblast growth factor by breast cancer cells within some tumours may contribute to their development.

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Year:  1994        PMID： 7511406      PMCID： PMC1968831          DOI： 10.1038/bjc.1994.146

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  21 in total

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Journal:  J Cell Sci       Date:  1993-09       Impact factor: 5.285
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  22 in total

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Journal:  J Clin Pathol       Date:  2001-01       Impact factor: 3.411

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4.  RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3.

Authors:  Katia Cailliau; Arlette Lescuyer; Anne-Françoise Burnol; Álvaro Cuesta-Marbán; Christian Widmann; Edith Browaeys-Poly
Journal:  J Biol Chem       Date:  2015-06-24       Impact factor: 5.157

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Journal:  Mol Cell Biol       Date:  1998-10       Impact factor: 4.272

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Authors:  G Montrucchio; A Sapino; B Bussolati; G Ghisolfi; S Rizea-Savu; L Silvestro; E Lupia; G Camussi
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Authors:  Marina P Silva; Danilo F Soave; Alfredo Ribeiro-Silva; Martin E Poletti
Journal:  BMC Res Notes       Date:  2012-07-06

10.  Expression of keratinocyte growth factor and its receptor in human breast cancer.

Authors:  G S Bansal; H C Cox; S Marsh; J J Gomm; C Yiangou; Y Luqmani; R C Coombes; C L Johnston
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640
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