Literature DB >> 7510605

Antitumor, anti-inflammatory and analgesic property of embelin, a plant product.

M Chitra1, E Sukumar, V Suja, C S Devi.   

Abstract

Embelin, a plant-based benzoquinone derivative, has been found to exhibit significant antitumor activity in methylcholanthrene-induced fibrosarcoma in albino rats besides enhancing their survival time. The drug also has an appreciable action on pain and inflammation. The changes in DNA, RNA and protein levels in various organs in the tumor-bearing control and the drug-treated animals were also studied.

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Year:  1994        PMID： 7510605     DOI： 10.1159/000239181

Source DB:  PubMed          Journal:  Chemotherapy        ISSN： 0009-3157            Impact factor:   2.544


  38 in total

1.  PEG-derivatized embelin as a dual functional carrier for the delivery of paclitaxel.

Authors:  Yixian Huang; Jianqin Lu; Xiang Gao; Jiang Li; Wenchen Zhao; Ming Sun; Donna Beer Stolz; Raman Venkataramanan; Lisa Cencia Rohan; Song Li
Journal:  Bioconjug Chem       Date:  2012-06-20       Impact factor: 4.774

Review 2.  Natural products and their role in cancer therapy.

Authors:  David Siu
Journal:  Med Oncol       Date:  2010-04-23       Impact factor: 3.064

3.  Protective effect of embelin from Embelia ribes Burm. against transient global ischemia-induced brain damage in rats.

Authors:  B S Thippeswamy; P Nagakannan; B D Shivasharan; S Mahendran; V P Veerapur; S Badami
Journal:  Neurotox Res       Date:  2011-07-13       Impact factor: 3.911

4.  Ellagic acid and embelin affect key cellular components of pancreatic adenocarcinoma, cancer, and stellate cells.

Authors:  Mouad Edderkaoui; Aurelia Lugea; Hongxiang Hui; Guido Eibl; Qing-Yi Lu; Aune Moro; Xuyang Lu; Gang Li; Vay-Liang Go; Stephen J Pandol
Journal:  Nutr Cancer       Date:  2013-10-15       Impact factor: 2.900

5.  Natural IAP inhibitor Embelin enhances therapeutic efficacy of ionizing radiation in prostate cancer.

Authors:  Yao Dai; Jeffrey Desano; Yang Qu; Wenhua Tang; Yang Meng; Theodore S Lawrence; Liang Xu
Journal:  Am J Cancer Res       Date:  2011       Impact factor: 6.166

6.  Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.

Authors:  Bharat B Aggarwal; Sahdeo Prasad; Simone Reuter; Ramaswamy Kannappan; Vivek R Yadev; Byoungduck Park; Ji Hye Kim; Subash C Gupta; Kanokkarn Phromnoi; Chitra Sundaram; Seema Prasad; Madan M Chaturvedi; Bokyung Sung
Journal:  Curr Drug Targets       Date:  2011-10       Impact factor: 3.465

7.  Protective effects of embelin on myocardial ischemia-reperfusion injury following cardiac arrest in a rabbit model.

Authors:  Zhi-Gang Zhao; Zhong-Zhi Tang; Wen-Kai Zhang; Jian-Guo Li
Journal:  Inflammation       Date:  2015-04       Impact factor: 4.092

8.  Embelin Reduces Systemic Inflammation and Ameliorates Organ Injuries in Septic Rats Through Downregulating STAT3 and NF-κB Pathways.

Authors:  Xian-Long Zhou; Lei Huang; Jun Cao
Journal:  Inflammation       Date:  2015-08       Impact factor: 4.092

9.  Activation of endothelial nitric oxide synthase by the pro-apoptotic drug embelin: Striking discrepancy between nitric oxide-mediated cyclic GMP accumulation and L-citrulline formation.

Authors:  Kurt Schmidt; Jens Martens-Lobenhoffer; Andreas Meinitzer; Wolfgang F Graier; Christina M Torres; Richard C Venema; Bernd Mayer
Journal:  Nitric Oxide       Date:  2010-02-06       Impact factor: 4.427

10.  Phytochemical analysis, antioxidant activities and optimized extraction of embelin from different genotypes of Embelia ribes Burm f.: a woody medicinal climber from Western Ghats of India.

Authors:  Vidya Kamble; Usmangani Attar; Suraj Umdale; Mansingraj Nimbalkar; Savaliram Ghane; Nikhil Gaikwad
Journal:  Physiol Mol Biol Plants       Date:  2020-08-14
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