Literature DB >> 7501458

Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators.

C Cooper1, A Henderson, S Artandi, N Avitahl, K Calame.   

Abstract

Analysis of cDNA and genomic clones shows that the murine Ig/EBP (C/EBP gamma) gene encodes a small protein with a predicted molecular weight of 16.4 kDa which contains C/EBP family basic and leucine zipper domains but lacks the transcriptional activation domains present in C/EBP (C/EBP alpha) and NF-IL6 (C/EBP beta). In transfection assays Ig/EBP is neither an activator nor a repressor of transcription; however, Ig/EBP inhibits the transcriptional ability of NF-IL6 (C/EBP beta) and C/EBP (C/EBP alpha), acting as a transdominant negative regulator. Thus Ig/EBP resembles LIP, another negative regulator of the C/EBP family, in both structure and transcriptional activity. Of the three known C/EBP family inhibitors, Ig/EBP, LIP and CHOP-10, only Ig/EBP is ubiquitously expressed. Therefore, Ig/EBP may act as a general buffer for C/EBP activators in many cell types.

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Year:  1995        PMID： 7501458      PMCID： PMC307392          DOI： 10.1093/nar/23.21.4371

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  49 in total

1.  CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription.

Authors:  N S Foulkes; E Borrelli; P Sassone-Corsi
Journal:  Cell       Date:  1991-02-22       Impact factor: 41.582

2.  Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses.

Authors:  P F Johnson; W H Landschulz; B J Graves; S L McKnight
Journal:  Genes Dev       Date:  1987-04       Impact factor: 11.361

3.  Binding in vitro of multiple cellular proteins to immunoglobulin heavy-chain enhancer DNA.

Authors:  C L Peterson; K Orth; K L Calame
Journal:  Mol Cell Biol       Date:  1986-12       Impact factor: 4.272

4.  The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite.

Authors:  W H Landschulz; P F Johnson; S L McKnight
Journal:  Science       Date:  1989-03-31       Impact factor: 47.728

5.  The interplay of DNA-binding proteins on the promoter of the mouse albumin gene.

Authors:  S Lichtsteiner; J Wuarin; U Schibler
Journal:  Cell       Date:  1987-12-24       Impact factor: 41.582

6.  Purified mu EBP-E binds to immunoglobulin enhancers and promoters.

Authors:  C L Peterson; S Eaton; K Calame
Journal:  Mol Cell Biol       Date:  1988-11       Impact factor: 4.272

7.  Complex protein binding within the mouse immunoglobulin heavy-chain enhancer.

Authors:  C L Peterson; K L Calame
Journal:  Mol Cell Biol       Date:  1987-12       Impact factor: 4.272

8.  LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.

Authors:  P Descombes; M Chojkier; S Lichtsteiner; E Falvey; U Schibler
Journal:  Genes Dev       Date:  1990-09       Impact factor: 11.361

9.  Identification of sequences responsible for acute-phase induction of human C-reactive protein.

Authors:  R Arcone; G Gualandi; G Ciliberto
Journal:  Nucleic Acids Res       Date:  1988-04-25       Impact factor: 16.971

10.  Three levels of functional interaction determine the activity of CCAAT/enhancer binding protein-alpha on the serum albumin promoter.

Authors:  C Nerlov; E B Ziff
Journal:  Genes Dev       Date:  1994-02-01       Impact factor: 11.361
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  42 in total

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Authors:  C Schwartz; P Catez; O Rohr; D Lecestre; D Aunis; E Schaeffer
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4.  An integrative model for alternative polyadenylation, IntMAP, delineates mTOR-modulated endoplasmic reticulum stress response.

Authors:  Jae-Woong Chang; Wei Zhang; Hsin-Sung Yeh; Meeyeon Park; Chengguo Yao; Yongsheng Shi; Rui Kuang; Jeongsik Yong
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5.  Suppressor of cytokine signaling 3 inhibits LPS-induced IL-6 expression in osteoblasts by suppressing CCAAT/enhancer-binding protein {beta} activity.

Authors:  Chunguang Yan; Jay Cao; Min Wu; Wei Zhang; Tao Jiang; Aihiko Yoshimura; Hongwei Gao
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Review 6.  CCAAT/enhancer-binding proteins and the pathogenesis of retrovirus infection.

Authors:  Yujie Liu; Michael R Nonnemacher; Brian Wigdahl
Journal:  Future Microbiol       Date:  2009-04       Impact factor: 3.165

7.  C/EBPγ suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPβ.

Authors:  Christopher J Huggins; Radek Malik; Sook Lee; Jacqueline Salotti; Sara Thomas; Nancy Martin; Octavio A Quiñones; W Gregory Alvord; Mary E Olanich; Jonathan R Keller; Peter F Johnson
Journal:  Mol Cell Biol       Date:  2013-06-17       Impact factor: 4.272

8.  RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity.

Authors:  Sook Lee; Jon D Shuman; Tad Guszczynski; Krisada Sakchaisri; Thomas Sebastian; Terry D Copeland; Maria Miller; Michael S Cohen; Jack Taunton; Robert C Smart; Zhen Xiao; Li-Rong Yu; Timothy D Veenstra; Peter F Johnson
Journal:  Mol Cell Biol       Date:  2010-03-29       Impact factor: 4.272

Review 9.  Transcriptional control of natural killer cell differentiation and function.

Authors:  Alfonso Martín-Fontecha; Graham M Lord; Hugh J M Brady
Journal:  Cell Mol Life Sci       Date:  2011-08-24       Impact factor: 9.261

10.  Production of a monoclonal antibody for C/EBPβ: the subnuclear localization of C/EBPβ in mouse L929 cells.

Authors:  Akihito Harada; Etsuko Okazaki; Seiji Okada; Taro Tachibana; Yasuyuki Ohkawa
Journal:  Monoclon Antib Immunodiagn Immunother       Date:  2014-02
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