Literature DB >> 3690666

The interplay of DNA-binding proteins on the promoter of the mouse albumin gene.

S Lichtsteiner1, J Wuarin, U Schibler.   

Abstract

The promoter of the mouse albumin gene contains at least six binding sites for specific DNA-binding proteins (A to F). Four of these sites (A, D, E, and F) can be occupied by transcription factors that are considerably enriched in liver nuclei, as compared to spleen or brain nuclei. These factors consist of a heat-stable protein that fills sites A, D, and F, and a member of a family of nuclear factor I (NF-I) related proteins that occupies site E. Site C binds a protein that is equally abundant in liver, brain, and spleen nuclei. Occupancy of this site and the binding of the heat-stable factor to the immediately adjacent site D appear to be mutually exclusive. However, both of these competing binding sites are required for maximal in vitro transcription.

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Year:  1987        PMID： 3690666     DOI： 10.1016/0092-8674(87)90583-6

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  185 in total

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Journal:  Mol Cell Biol       Date:  1990-01       Impact factor: 4.272

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Journal:  Nucleic Acids Res       Date:  1991-03-11       Impact factor: 16.971

8.  The rat albumin promoter: cooperation with upstream elements is required when binding of APF/HNF1 to the proximal element is partially impaired by mutation or bacterial methylation.

Authors:  F Tronche; A Rollier; I Bach; M C Weiss; M Yaniv
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