Literature DB >> 7494317

The coxsackievirus A9 RGD motif is not essential for virus viability.

P J Hughes1, C Horsnell, T Hyypiä, G Stanway.   

Abstract

An RGD (arginine-glycine-aspartic acid) motif in coxsackievirus A9 has been implicated in internalization through an interaction with the integrin alpha v beta 3. We have produced a number of virus mutants, lacking the motif, which have a small-plaque phenotype in LLC-Mk2 and A-Vero cells and are phenotypically normal in RD cells. Substitution of flanking amino acids also affected plaque size. The results suggest that interaction between the RGD motif and alpha v beta 3 is not critical for virus viability in the cell lines tested and therefore that alternative regions of the CAV-9 capsid are involved in internalization.

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Year:  1995        PMID： 7494317      PMCID： PMC189749     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  40 in total

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5.  Identification of monoclonal antibody epitopes and critical residues for rhinovirus binding in domain 1 of intercellular adhesion molecule 1.

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6.  [Is the Arg-Gly-Asp sequence the site for foot-and-mouth disease virus binding with cell receptor?].

Authors:  A Iu Surovoĭ; V T Ivanov; A V Chepurkin; V N Ivaniushchenkov; N N Driagalin
Journal:  Bioorg Khim       Date:  1988-07

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Authors:  K H Chang; P Auvinen; T Hyypiä; G Stanway
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Authors:  G Stanway; N Kalkkinen; M Roivainen; F Ghazi; M Khan; M Smyth; O Meurman; T Hyypiä
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10.  Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization.

Authors:  T J Wickham; E J Filardo; D A Cheresh; G R Nemerow
Journal:  J Cell Biol       Date:  1994-10       Impact factor: 10.539
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  24 in total

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Authors:  Mohammed Al-Sunaidi; Cigdem H Williams; Pamela J Hughes; David P Schnurr; Glyn Stanway
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4.  An RNA tertiary structure in the 3' untranslated region of enteroviruses is necessary for efficient replication.

Authors:  M H Mirmomeni; P J Hughes; G Stanway
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5.  Tissue culture adaptation of foot-and-mouth disease virus selects viruses that bind to heparin and are attenuated in cattle.

Authors:  D Sa-Carvalho; E Rieder; B Baxt; R Rodarte; A Tanuri; P W Mason
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6.  Efficient RGD-independent entry process of coxsackievirus A9.

Authors:  M Roivainen; L Piirainen; T Hovi
Journal:  Arch Virol       Date:  1996       Impact factor: 2.574

7.  Human Memory B Cells Producing Potent Cross-Neutralizing Antibodies against Human Parechovirus: Implications for Prevalence, Treatment, and Diagnosis.

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Journal:  J Virol       Date:  2015-05-06       Impact factor: 5.103

8.  Terminal RNA replication elements in human parechovirus 1.

Authors:  Abdolrahman S Nateri; Pamela J Hughes; Glyn Stanway
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

9.  Coxsackievirus A9 VP1 mutants with enhanced or hindered A particle formation and decreased infectivity.

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Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

10.  Structural and functional analysis of coxsackievirus A9 integrin αvβ6 binding and uncoating.

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Journal:  J Virol       Date:  2013-01-30       Impact factor: 5.103
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