Literature DB >> 11559835

Arginine-glycine-aspartic acid motif is critical for human parechovirus 1 entry.

Y Boonyakiat1, P J Hughes, F Ghazi, G Stanway.   

Abstract

The human parechovirus 1 RGD motif in VP1 was studied by mutagenesis. An RGD-to-RGE change gave only revertant viruses with a restored RGD, while deletion of GD was lethal and nonrevertable. Mutations at the +1 and +2 positions had some effect on growth properties and a +1 M-to-P change was lethal. These studies indicate that the RGD motif plays a critical role in infectivity, presumably by interacting with integrins, and that downstream amino acids can have an influence on function.

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Year:  2001        PMID： 11559835      PMCID： PMC114574          DOI： 10.1128/JVI.75.20.10000-10004.2001

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  51 in total

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