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Literature DB >> 7479895

How is the Human Genome Project doing, and what have we learned so far?

Abstract

In this paper, we describe the accomplishments of the initial phase of the Human Genome Project, with particular attention to the progress made toward achieving the defined goals for constructing genetic and physical maps of the human genome and determining the sequence of human DNA, identifying the complete set of human genes, and analyzing the need for adequate policies for using the information about human genetics in ways that maximize the benefits for individuals and society.

Entities: Species

Mesh：

Substances：
Genetic Markers

Year: 1995 PMID： 7479895 PMCID： PMC40527 DOI： 10.1073/pnas.92.24.10841

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

83 in total

1. Integration of physical, breakpoint and genetic maps of chromosome 22. Localization of 587 yeast artificial chromosomes with 238 mapped markers.

Authors: C J Bell; M L Budarf; B W Nieuwenhuijsen; B L Barnoski; K H Buetow; K Campbell; A M Colbert; J Collins; M Daly; P R Desjardins
Journal: Hum Mol Genet Date: 1995-01 Impact factor: 6.150

2. FGFR2 mutations in Pfeiffer syndrome.

Authors: E Lajeunie; H W Ma; J Bonaventure; A Munnich; M Le Merrer; D Renier
Journal: Nat Genet Date: 1995-02 Impact factor: 38.330

3. A strategy for sequencing the genome 5 years early.

Authors: E Marshall
Journal: Science Date: 1995-02-10 Impact factor: 47.728

Review 4. Fishing for complements: finding genes by direct selection.

Authors: M Lovett
Journal: Trends Genet Date: 1994-10 Impact factor: 11.639

5. The rise and fall of positional cloning?

Authors: A Ballabio
Journal: Nat Genet Date: 1993-04 Impact factor: 38.330

6. A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome.

Authors: M Muenke; U Schell; A Hehr; N H Robin; H W Losken; A Schinzel; L J Pulleyn; P Rutland; W Reardon; S Malcolm
Journal: Nat Genet Date: 1994-11 Impact factor: 38.330

7. Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2.

Authors: E W Jabs; X Li; A F Scott; G Meyers; W Chen; M Eccles; J I Mao; L R Charnas; C E Jackson; M Jaye
Journal: Nat Genet Date: 1994-11 Impact factor: 38.330

8. Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome.

Authors: A O Wilkie; S F Slaney; M Oldridge; M D Poole; G J Ashworth; A D Hockley; R D Hayward; D J David; L J Pulleyn; P Rutland
Journal: Nat Genet Date: 1995-02 Impact factor: 38.330

9. Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes.

Authors: P Rutland; L J Pulleyn; W Reardon; M Baraitser; R Hayward; B Jones; S Malcolm; R M Winter; M Oldridge; S F Slaney
Journal: Nat Genet Date: 1995-02 Impact factor: 38.330

10. Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome.

Authors: W Reardon; R M Winter; P Rutland; L J Pulleyn; B M Jones; S Malcolm
Journal: Nat Genet Date: 1994-09 Impact factor: 38.330

13 in total

1. A genetic strategy to eliminate self-activator baits prior to high-throughput yeast two-hybrid screens.

Authors: A J Walhout; M Vidal
Journal: Genome Res Date: 1999-11 Impact factor: 9.043

2. A library-based bioinformatics services program.

Authors: S Yarfitz; D S Ketchell
Journal: Bull Med Libr Assoc Date: 2000-01

3. Scientific limitations and ethical ramifications of a non-representative Human Genome Project: African American response.

Authors: Fatimah Jackson
Journal: Sci Eng Ethics Date: 1998-04 Impact factor: 3.525

4. A ribozyme-mediated, gene "knockdown" strategy for the identification of gene function in zebrafish.

Authors: Y Xie; X Chen; T E Wagner
Journal: Proc Natl Acad Sci U S A Date: 1997-12-09 Impact factor: 11.205

5. Sequence tag identification of intact proteins by matching tanden mass spectral data against sequence data bases.

Authors: E Mørtz; P B O'Connor; P Roepstorff; N L Kelleher; T D Wood; F W McLafferty; M Mann
Journal: Proc Natl Acad Sci U S A Date: 1996-08-06 Impact factor: 11.205

6. Missense mutations in disease genes: a Bayesian approach to evaluate causality.

Authors: G M Petersen; G Parmigiani; D Thomas
Journal: Am J Hum Genet Date: 1998-06 Impact factor: 11.025

7. Highly selective isolation of human DNAs from rodent-human hybrid cells as circular yeast artificial chromosomes by transformation-associated recombination cloning.

Authors: V Larionov; N Kouprina; J Graves; M A Resnick
Journal: Proc Natl Acad Sci U S A Date: 1996-11-26 Impact factor: 11.205