Literature DB >> 7461852

Identification of potential carcinogens in technical grade 1,1,1-trichloroethane.

D Henschler, D Reichert, M Metzler.   

Abstract

Gas chromatography and gas chromatography-mass spectrometry were employed to analyze 22 samples of technical grade 1,1,1-trichloroethane for impurities. Eighteen contained vinylidene chloride (1,1-dichloroethylene) (30-900 micrograms/ml) and further contaminants were identified as 1,1-dichloroethane (11), trichloroethylene (12), and 1,1,2-trichloroethane (9). Nitromethane (18), 1,2-epoxybutane (19), tert. butanol (7), and dioxane (10) were detected as stabilizers. It is recommended that the manufacturers should eliminate vinylidene chloride and stabilizers which carry a carcinogenic and/or mutagenic risk, from technical samples of 1,1,1-trichloroethane.

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Year:  1980        PMID： 7461852     DOI： 10.1007/bf00381683

Source DB:  PubMed          Journal:  Int Arch Occup Environ Health        ISSN： 0340-0131            Impact factor:   3.015


  9 in total

1.  Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxiran formation.

Authors:  H Greim; G Bonse; Z Radwan; D Reichert; D Henschler
Journal:  Biochem Pharmacol       Date:  1975-11-01       Impact factor: 5.858

2.  Liver necrosis and the induction of carbon tetrachloride hepatomas in strain A mice.

Authors:  A B ESCHENBRENNER; E MILLER
Journal:  J Natl Cancer Inst       Date:  1946-06       Impact factor: 13.506

3.  Carcinogenicity bioassays of vinyl chloride: current results.

Authors:  C Maltoni; G Lefemine
Journal:  Ann N Y Acad Sci       Date:  1975-01-31       Impact factor: 5.691

4.  Carcinogenicity of trichloroethylene: fact or artifact?

Authors:  D Henschler; E Eder; T Neudecker; M Metzler
Journal:  Arch Toxicol       Date:  1977-07-19       Impact factor: 5.153

5.  Oncogenic response of rat skin, lungs, and bones to vinyl chloride.

Authors:  P L Viola; A Bigotti; A Caputo
Journal:  Cancer Res       Date:  1971-05       Impact factor: 12.701

6.  Transforming activities of trichloroethylene and proposed industrial alternatives.

Authors:  P J Price; C M Hassett; J I Mansfield
Journal:  In Vitro       Date:  1978-03

7.  Carcinogenicity of vinyl chloride and vinylidene chloride.

Authors:  C C Lee; J C Bhandari; J M Winston; W B House; R L Dixon; J S Woods
Journal:  J Toxicol Environ Health       Date:  1978-01

8.  Carcinogenicity studies on halogenated hydrocarbons.

Authors:  E K Weisburger
Journal:  Environ Health Perspect       Date:  1977-12       Impact factor: 9.031

9.  Carcinogenicity studies on vinylidene chloride.

Authors:  P L Viola; A Caputo
Journal:  Environ Health Perspect       Date:  1977-12       Impact factor: 9.031
  9 in total
  2 in total

1.  Carcinogenicity study of trichloroethylene, with and without epoxide stabilizers, in mice.

Authors:  D Henschler; H Elsässer; W Romen; E Eder
Journal:  J Cancer Res Clin Oncol       Date:  1984       Impact factor: 4.553

2.  Activities of chlorinated ethane and ethylene compounds in the Salmonella/rat microsome mutagenesis and rat hepatocyte/DNA repair assays under vapor phase exposure conditions.

Authors:  T Shimada; A F Swanson; P Leber; G M Williams
Journal:  Cell Biol Toxicol       Date:  1985-06       Impact factor: 6.691
  2 in total

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