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Literature DB >> 332116

Carcinogenicity of trichloroethylene: fact or artifact?

D Henschler, E Eder, T Neudecker, M Metzler.

Abstract

Technical trichloroethylene has been found carcinogenic in mice after high daily doses per os. A GC-MS analysis of this technical sample revealed the presence of considerable amounts of epichlorohydrin and 1.2-epoxibutane as stabilizers. These epoxides are highly mutagenic in the Ames test and are, most probably, responsible for the carcinogenic effect found in mice. The question whether trichloroethylene is carcinogenic or not remains open.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1977 PMID： 332116 DOI： 10.1007/bf00355492

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

7 in total

1. Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxiran formation.

Authors: H Greim; G Bonse; Z Radwan; D Reichert; D Henschler
Journal: Biochem Pharmacol Date: 1975-11-01 Impact factor: 5.858

Review 2. Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.

Authors: F Oesch
Journal: Xenobiotica Date: 1973-05 Impact factor: 1.908

Review 3. Chemical reactivity, biotransformation, and toxicity of polychlorinated aliphatic compounds.

Authors: G Bonse; D Henschler
Journal: CRC Crit Rev Toxicol Date: 1976-10

4. Carcnogenicity of epoxides, lactones, and peroxy compounds. VI. Structure and carcinogenic activity.

Authors: B L Van Duuren; L Langseth; B M Goldschmidt; L Orris
Journal: J Natl Cancer Inst Date: 1967-12 Impact factor: 13.506

5. Industrial mutagens and potential mutagens I. Halogenated aliphatic derivatives.

Authors: L Fishbein
Journal: Mutat Res Date: 1976 Impact factor: 2.433

6. Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection.

Authors: B N Ames; W E Durston; E Yamasaki; F D Lee
Journal: Proc Natl Acad Sci U S A Date: 1973-08 Impact factor: 11.205

7. Covalent interaction of metabolites of the carcinogen trichloroethylene in rat hepatic microsomes.

Authors: B L Van Duuren; S Banerjee
Journal: Cancer Res Date: 1976-07 Impact factor: 12.701

7 in total

20 in total

1. Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases.

Authors: H Bartsch; C Malaveille; A Barbin; G Planche
Journal: Arch Toxicol Date: 1979-02-23 Impact factor: 5.153

2. [Chromosome studies on trichloroethylene workers (author's transl)].

Authors: H Konietzko; W Haberlandt; H Heilbronner; G Reill; H Weichardt
Journal: Arch Toxicol Date: 1978-06-16 Impact factor: 5.153

Review 3. Procedures for screening chemicals for carcinogenicity.

Authors: I F Purchase
Journal: Br J Ind Med Date: 1980-02

4. Covalent binding of drug metabolites to DNA--a tool of predictive value?

Authors: H M Bolt; R J Laib
Journal: Arch Toxicol Date: 1980-11 Impact factor: 5.153

5. In vivo suppression of 1,1,1-trichloroethane metabolism by co-administered tetrachloroethylene: an inhalation study.

Authors: A Koizumi; M Kumai; M Ikeda
Journal: Bull Environ Contam Toxicol Date: 1982-08 Impact factor: 2.151

6. Vinyl chloride and trichloroethylene: comparison of alkylating effects of metabolites and induction of preneoplastic enzyme deficiencies in rat liver.

Authors: R J Laib; G Stöckle; H M Bolt; W Kunz
Journal: J Cancer Res Clin Oncol Date: 1979-06-08 Impact factor: 4.553