Literature DB >> 7458419

Immunohistochemical location of placental proteins (PP8, 9, 10, 11, 12) in human term placentae.

N Inaba, T Renk, H Bohn.   

Abstract

By using an immunoglobulin enzyme bridge (PAP) technique, the location of two ubiquitous tissue proteins (PP8, PP9) and three placental specific tissue proteins (PP10, PP11, PP12) was investigated in ethanol/acetic acid-fixed paraffin-embedded human term placentae. PP8 was found mainly in both the cytoplasm and the nucleus of trophoblast cells (chorion) and syncytiotrophoblast (villi). PP9 was found in the cytoplasm of trophoblast cells (chorion), the fibrous part of interstitial connective tissues (villi), and the cytoplasm of histiocytes (villi, amnion, and decidua). PP10 was found in the cytoplasm of epithelium (amnion) and in both the cytoplasm and the nucleus of syncytiotrophoblast (villi). PP12 was found in the cytoplasm of histiocytes in decidua, amnion, and chorion and the cytoplasm of syncytiotrophoblast (villi). In addition, stains for PP8, PP10, and PP12 were taken up by the cytoplasm of histiocytes found in amnion, villi, the intervillous space, and decidua, in contrast to PP11, which was found to be specific to the cytoplasm of trophoblast cells (chorion and villi). Possible clinical applications of these findings are discussed.

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Year:  1980        PMID： 7458419     DOI： 10.1007/bf02108266

Source DB:  PubMed          Journal:  Arch Gynecol        ISSN： 0170-9925


  15 in total

1.  Immunohistochemical studies on human gastric mucosa. Procedures for routine demonstration of gastric proteins by immunoenzyme techniques.

Authors:  K Wurster; W D Kuhlmann; W Rapp
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1978-06-15

2.  The unmasking of antigens in paraffin sections of tissue by trypsin.

Authors:  R C Curran; J Gregory
Journal:  Experientia       Date:  1977-10-15

3.  Letter: Destruction of endogenous peroxidase activity in order to locate cellular antigens by peroxidase-labeled antibodies.

Authors:  A Pitts; E E Williams
Journal:  J Histochem Cytochem       Date:  1974-01       Impact factor: 2.479

4.  [Isolation and characterization of a new placenta specific protein (PP12) (author's transl)].

Authors:  H Bohn; W Kraus
Journal:  Arch Gynecol       Date:  1980

5.  [Isolation and characterization of a new placental tissue protein (PP11) (author's transl)].

Authors:  H Bohn; W Winckler
Journal:  Arch Gynecol       Date:  1980

6.  Background staining and sensitivity of the unlabelled antibody-enzyme (PAP) method. Comparison with the peroxidase labelled antibody sandwich method using formalin fixed paraffin embedded material.

Authors:  J Burns
Journal:  Histochemistry       Date:  1975-06-05

7.  [Isolation and characterization of a new placenta specific protein (PP10) (author's transl)].

Authors:  H Bohn; W Kraus
Journal:  Arch Gynecol       Date:  1979-08

8.  Prognostic significance of inappropriate production of pregnancy proteins by breast cancers.

Authors:  C H Horne; I N Reid; G D Milne
Journal:  Lancet       Date:  1976-08-07       Impact factor: 79.321

9.  Immunohistochemical location of proteins related to pregnancy-specific beta 1-glycoprotein (SP1) and placental tissue proteins (PP5, PP8, PP9, PP10, PP11, PP12) in the afterbirth of Cynomolgus monkeys (Macaca fascicularis).

Authors:  N Inaba; T Renk; E Weinmann; H Bohn
Journal:  Arch Gynecol       Date:  1981

Review 10.  New placental and pregnancy proteins as possible markers in oncology.

Authors:  H Bohn
Journal:  Klin Wochenschr       Date:  1980-05-16
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  17 in total

1.  In vitro and in vivo studies of the production of placental proteins (HCG, SP1, PPs) in human choriocarcinoma cell lines.

Authors:  S Sekiya; N Inaba; H Ishige; H Takamizawa; H Bohn
Journal:  Arch Gynecol Obstet       Date:  1987       Impact factor: 2.344

2.  Proteomic profile of uterine luminal fluid from early pregnant ewes.

Authors:  Jill M Koch; Jayanth Ramadoss; Ronald R Magness
Journal:  J Proteome Res       Date:  2010-08-06       Impact factor: 4.466

3.  AFP-producing Sertoli-Leydig cell tumor of the ovary.

Authors:  S Sekiya; N Inaba; H Iwasawa; O Kobayashi; H Takamizawa; O Matsuzaki; K Nagao
Journal:  Arch Gynecol       Date:  1985

4.  Immunohistochemical location of proteins related to pregnancy-specific beta 1-glycoprotein (SP1) and placental tissue proteins (PP5, PP8, PP9, PP10, PP11, PP12) in the afterbirth of Cynomolgus monkeys (Macaca fascicularis).

Authors:  N Inaba; T Renk; E Weinmann; H Bohn
Journal:  Arch Gynecol       Date:  1981

5.  Immunohistochemical detection of pregnancy and placental proteins in human and cynomolgus monkey (Macaca Fascicularis) peripheral blood cells.

Authors:  N Inaba; T Renk; W Ax; E Weinmann; S Schottler; H Bohn
Journal:  Blut       Date:  1981-11

6.  Serum levels of placental protein 10 (PP10) in women with breast cancer and genital carcinoma and in healthy male and female subjects.

Authors:  H Würz; G Lüben; H Bohn
Journal:  Arch Gynecol       Date:  1983

7.  Human endometrium and menstrual fluid contain placental protein 10 (PP10).

Authors:  A Tiitinen; R Bützow; R Koistinen; M Seppälä
Journal:  Arch Gynecol       Date:  1987

8.  Serum levels of placenta-specific tissue protein 12 (PP12) in pregnancies complicated by pre-eclampsia, diabetes or twins.

Authors:  G N Than; I F Csaba; D G Szabó; A A Arany; Z J Bognár; H Bohn
Journal:  Arch Gynecol       Date:  1984

9.  Concentration of placental protein 10 (PP10) in maternal serum and amniotic fluid throughout normal gestation and in pregnancy complicated by fetal growth retardation.

Authors:  H Würz; G Lüben; H Bohn; H J Künzig; W Geiger
Journal:  Arch Gynecol       Date:  1983

10.  Placental protein 12 (PP 12), a decidual protein, in pregnancy complicated by diabetes with retinopathy.

Authors:  V Briese; E Glöckner; G N Than; D G Szabo; R R Strache
Journal:  Arch Gynecol Obstet       Date:  1989       Impact factor: 2.344
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