| Literature DB >> 7451615 |
J F Strauss, R L Kitchens, V W Patrizi, E P Frenkel.
Abstract
The measurement of intracellular concentrations of the anti-cancer drug doxorubicin was performed by the application of a simple cell extraction technique combined with a rapid high-performance liquid chromatographic separation. Quantitation was done by fluorescence detection. The extraction procedure was non-degradative and the mean recovery of drug was 95%. A high drug extraction efficiency was confirmed with radiolabeled [3H] doxorubicin. The method is applicable to normal and neoplastic tissue.Entities:
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Year: 1980 PMID： 7451615 DOI： 10.1016/s0378-4347(00)81015-4
Source DB: PubMed Journal: J Chromatogr