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Literature DB >> 6205782

Daunomycin-arachidonic acid complex as a potential new antitumor agent.

T Sasaki, Y Tsukada, H F Deutsch, H Hirai.

Abstract

A daunomycin-arachidonic acid complex (DM-C20:4) administered IV had a marked antitumor effect on the intraperitoneal growth of the AFP-producing hepatoma cell line, AH66. However, the daunomycin-arachidic acid (DM-C20:0) saturated fatty acid complex showed only the same antitumor effect on the AH66 cells as free daunomycin. It was demonstrated that the DM-C20:4 preparation maintained its chemical properties for some time in both plasma and liver homogenate.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1984 PMID： 6205782 DOI： 10.1007/bf00257117

Source DB: PubMed Journal: Cancer Chemother Pharmacol ISSN： 0344-5704 Impact factor: 3.333

11 in total

1. Inhibition of tumour growth in vivo and in vitro by prostaglandin E.

Authors: M G Santoro; G W Philpott; B M Jaffe
Journal: Nature Date: 1976-10-28 Impact factor: 49.962

2. Phospholipid metabolism of stimulated lymphocytes: activation of acyl-CoA:lysolecithin acyltransferases in microsomal membranes.

Authors: E Ferber; K Resch
Journal: Biochim Biophys Acta Date: 1973-02-14

3. Extraction and quantification of daunomycin and doxorubicin in tissues.

Authors: J F Strauss; R L Kitchens; V W Patrizi; E P Frenkel
Journal: J Chromatogr Date: 1980-11-14

4. Cytotoxic effects of daunomycin-fatty acid complexes on rat hepatoma cells.

Authors: H F Deutsch; Y Tsukada; T Sasaki; H Hirai
Journal: Cancer Res Date: 1983-06 Impact factor: 12.701

Review 5. Oncostatic-antibody complexes in chemotherapy.

Authors: H F Dullens; R A De Weger
Journal: Cancer Chemother Pharmacol Date: 1980 Impact factor: 3.333

6. Effect of a conjugate of daunomycin and antibodies to rat alpha-fetoprotein on the growth of alpha-fetoprotein-producing tumor cells.

Authors: Y Tsukada; W K Bischof; N Hibi; H Hirai; E Hurwitz; M Sela
Journal: Proc Natl Acad Sci U S A Date: 1982-01 Impact factor: 11.205

Daunomycin-arachidonic acid complex as a potential new antitumor agent.

1. Inhibition of tumour growth in vivo and in vitro by prostaglandin E.

2. Phospholipid metabolism of stimulated lymphocytes: activation of acyl-CoA:lysolecithin acyltransferases in microsomal membranes.

3. Extraction and quantification of daunomycin and doxorubicin in tissues.

4. Cytotoxic effects of daunomycin-fatty acid complexes on rat hepatoma cells.

Review 5. Oncostatic-antibody complexes in chemotherapy.

6. Effect of a conjugate of daunomycin and antibodies to rat alpha-fetoprotein on the growth of alpha-fetoprotein-producing tumor cells.

7. Human alpha-fetoprotein-fatty acid interaction.

Review 8. Antibody-linked cytotoxic agents in the treatment of cancer: current status and future prospects.

9. The fatty acid levels of rat alpha-fetoprotein derived from fetuses, pregnancy and hepatoma sera.

10. The presence of fatty acids in human alpha-fetoprotein.

Review 1. Antibody-mediated targeting in the treatment and diagnosis of cancer: an overview.

2. The Electrospray Ionization - Mass Spectra of Erythromycin A Obtained from a Marine Streptomyces sp. Mutant.