Literature DB >> 7444440

Relation of mammalian sperm chromatin heterogeneity to fertility.

D P Evenson, Z Darzynkiewicz, M R Melamed.   

Abstract

Flow cytometry of heated sperm nuclei revealed a significant decrease in resistance to in situ denaturation of spermatozoal DNA in samples from bulls, mice, and humans of low or questionable fertility when compared with others of high fertility. Since thermal denaturation of DNA in situ depends on chromatin structure, it is assumed that changes in sperm chromatin conformation may be related to the diminished fertility. Flow cytometry of heated sperm nuclei may provide a new and independent determinant of male fertility.

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Year:  1980        PMID： 7444440     DOI： 10.1126/science.7444440

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  93 in total

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Review 3.  Sperm chromatin structure assay (SCSA): a tool in diagnosis and treatment of infertility.

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4.  Reduced senescence and retained nuclear DNA integrity in human spermatozoa prepared by density gradient centrifugation.

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Journal:  J Assist Reprod Genet       Date:  2004-06       Impact factor: 3.412

5.  Relation between different human sperm nuclear maturity tests and in vitro fertilization.

Authors:  M H Nasr-Esfahani; S Razavi; M Mardani
Journal:  J Assist Reprod Genet       Date:  2001-04       Impact factor: 3.412

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Review 7.  Flow cytometry for the assessment of animal sperm integrity and functionality: state of the art.

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Journal:  Asian J Androl       Date:  2011-04-11       Impact factor: 3.285

8.  Sperm single-stranded DNA, detected by acridine orange staining, reduces fertilization and quality of ICSI-derived embryos.

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Journal:  J Assist Reprod Genet       Date:  2002-07       Impact factor: 3.412

Review 9.  Sperm DNA damage in male infertility: etiologies, assays, and outcomes.

Authors:  Ryan T Schulte; Dana A Ohl; Mark Sigman; Gary D Smith
Journal:  J Assist Reprod Genet       Date:  2009-12-12       Impact factor: 3.412

10.  Sperm DNA oxidative damage and DNA adducts.

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