Literature DB >> 1268820

Effects of adriamycin on ultrastructure of nucleoli in the heart and liver cells of the rat.

J A Merski, I Daskal, H Busch.   

Abstract

Ultrastructural studies of the effects of adriamycin on liver and cardiac cell nucleoli of the rat showed that nucleolar segregation occurred within 1 hr after an i.v. injection of a 40-mg/kg dose. Between 3 and 27 hr after this single dose, liver cell nucleoli progressively reverted to a normal ultrastructure. Nucleoli of rat myocardial cells did not recover but underwent further fragmentation, segragation, and conversion to ring-shaped structures. The ultrastructural alterations of myocardial cell nucleoli may represent an important aspect of adriamycin toxicity.

Entities:  

Mesh：

Substances：

Year:  1976        PMID： 1268820

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  10 in total

1.  Cytomorphological lesions induced by chemotherapeutic agents in transitional cell carcinoma in vitro.

Authors:  D J Weaver; B A Barrett; G Ross; E H Adelstein
Journal:  In Vitro Cell Dev Biol       Date:  1986-11

Review 2.  Antineoplastic drugs: clinical pharmacology and therapeutic use.

Authors:  R A Bender; L A Zwelling; J H Doroshow; G Y Locker; K R Hande; D S Murinson; M Cohen; C E Myers; B A Chabner
Journal:  Drugs       Date:  1978-07       Impact factor: 9.546

3.  Recessive TAF1A mutations reveal ribosomopathy in siblings with end-stage pediatric dilated cardiomyopathy.

Authors:  Pamela A Long; Jeanne L Theis; Yu-Huan Shih; Joseph J Maleszewski; Patrice C Abell Aleff; Jared M Evans; Xiaolei Xu; Timothy M Olson
Journal:  Hum Mol Genet       Date:  2017-08-01       Impact factor: 6.150

4.  Cytotoxic effects of adriamycin on mouse hypoglossal neurons following retrograde axonal transport from the tongue.

Authors:  L Bigotte; Y Olsson
Journal:  Acta Neuropathol       Date:  1983       Impact factor: 17.088

5.  Effects of 5-iminodaunorubicin on nucleoli of rats.

Authors:  J H Peters; M J Evans; R A Jensen; E M Acton
Journal:  Cancer Chemother Pharmacol       Date:  1980       Impact factor: 3.333

6.  Toxic effects of adriamycin on the central nervous system. Ultrastructural changes in some circumventricular organs of the mouse after intravenous administration of the drug.

Authors:  L Bigotte; Y Olsson
Journal:  Acta Neuropathol       Date:  1983       Impact factor: 17.088

7.  Nucleolar segregation as an early marker for DNA damage; an experimental study in rats treated with 4-hydroxyaminoquinoline 1-oxide.

Authors:  T Imazawa; A Nishikawa; M Tada; M Takahashi; Y Hayashi
Journal:  Virchows Arch       Date:  1995       Impact factor: 4.064

8.  The effects of cisplatin on rat spinal ganglia: a study by light and electron microscopy and by morphometry.

Authors:  K Tomiwa; C Nolan; J B Cavanagh
Journal:  Acta Neuropathol       Date:  1986       Impact factor: 17.088

Review 9.  Cardiac lesions induced by chemicals.

Authors:  T Balazs; V J Ferrans
Journal:  Environ Health Perspect       Date:  1978-10       Impact factor: 9.031

10.  Development and characterization of an in vitro model of colorectal adenocarcinoma with MDR phenotype.

Authors:  Lorenzo Cinci; Cristina Luceri; Elisabetta Bigagli; Ilaria Carboni; Sara Paccosi; Astrid Parenti; Daniele Guasti; Marcella Coronnello
Journal:  Cancer Med       Date:  2016-03-25       Impact factor: 4.452
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.