| Literature DB >> 7427022 |
J A Rennie, N D Christofides, P Mitchenere, D Fletcher, H L Stockley-Leathard, S R Bloom, A G Johnson, A J Rains.
Abstract
Two inhibitory mechanisms in the human colon which may contribute to postoperative ileus have been studied. Dopamine, a possible peripheral neurotransmitter, inhibited isolated colonic smooth muscle strips by a direct effect in longitudinal muscle any by a nerve-mediated mechanism as circular muscle. Plasma motilin levels were suppressed pre- and per- operatively and elevation of levels postoperatively correlated with the return of normal motility and the severity of the operation.Entities:
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Year: 1980 PMID： 7427022 DOI： 10.1002/bjs.1800671005
Source DB: PubMed Journal: Br J Surg ISSN： 0007-1323 Impact factor: 6.939