Literature DB >> 7418820

Non-linear kinetics of microsomal styrene monooxygenase after phenobarbital pre-treatment.

R Cantoni, E Vignazia, G Belvedere, L Cantoni, M Salmona.   

Abstract

Pretreatment of rats with phenobarbital, but not with 3-methylcholanthrene, induces liver microsomal styrene monooxygenase. Under these conditions the kinetic profile is not linear and can be divided into 2 distinct curves. Evidence is presented indicating that the combined treatment with phenobarbital and CoCl2 destroy the affinity enzyme, suggesting that the native cytochrome is less sensitive to the action of CoCl2.

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Year:  1980        PMID： 7418820     DOI： 10.1007/bf01970108

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  Purified liver microsomal cytochrome P-450. Separation and characterization of multiple forms.

Authors:  D A Haugen; T A van der Hoeven; M J Coon
Journal:  J Biol Chem       Date:  1975-05-10       Impact factor: 5.157

2.  Fractional solubilization of haemoproteins and partial purification of carbon monoxide-binding cytochrome from liver microsomes.

Authors:  T OMURA; R SATO
Journal:  Biochim Biophys Acta       Date:  1963-04-02

3.  Kinetic behaviour of microsomal styrene monooxygenase and styrene epoxide hydratase in different animal species.

Authors:  G Belvedere; L Cantoni; T Facchinetti; M Salmona
Journal:  Experientia       Date:  1977-06-15

4.  Separation, purification, and properties of multiple forms of cytochrome P-450 from the liver microsomes of phenobarbital-treated mice.

Authors:  M T Huang; S B West; A Y Lu
Journal:  J Biol Chem       Date:  1976-08-10       Impact factor: 5.157

5.  Characterisation of cytochrome P-450 species in rat liver microsomes, I. Differences in the O-dealkylation of 7-ethoxycoumarin after pretreatment with phenobarbital and 3-methylcholanthrene.

Authors:  V Ullrich; U Frommer; P Weber
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1973-05

6.  Epoxide intermediates in microsomal oxidation of olefins to glycols.

Authors:  K C Leibman; E Ortiz
Journal:  J Pharmacol Exp Ther       Date:  1970-06       Impact factor: 4.030

7.  The metabolism of styrene in the rat and the stimulatory effect of phenobarbital.

Authors:  H Otsuji; M Ikeda
Journal:  Toxicol Appl Pharmacol       Date:  1971-02       Impact factor: 4.219

8.  Phenobarbital inducible drug monooxygenase activity in the small intestine of mice.

Authors:  C Lehrmann; V Ullrich; W Rummel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

9.  Induction of multiple forms of mouse liver cytochrome P-450. Evidence for genetically controlled de novo protein synthesis in response to treatment with beta-naphthoflavone or phenobarbital.

Authors:  D A Haugen; M J Coon
Journal:  J Biol Chem       Date:  1976-03-25       Impact factor: 5.157

10.  Microsomal styrene mono-oxygenase and styrene epoxide hydrase activities in rats.

Authors:  M Salmona; J Pachecka; L Cantoni; G Belvedere; E Mussini; S Garattini
Journal:  Xenobiotica       Date:  1976-10       Impact factor: 1.908
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  3 in total

1.  Effect of iron and hemoproteins on hydrogen peroxide-supported styrene oxidation to styrene oxide.

Authors:  L Cantoni; D Blezza; G Belvedere
Journal:  Experientia       Date:  1982-10-15

2.  Styrene oxidation to styrene oxide in human erythrocytes is catalyzed by oxyhemoglobin.

Authors:  F Tursi; M Samaia; M Salmona; G Belvedere
Journal:  Experientia       Date:  1983-06-15

3.  Dinemorphan N-demethylation by mouse liver microsomes.

Authors:  P G Gervasi; D Benetti; L Citti; M Del Monte; G Turchi
Journal:  Experientia       Date:  1984-02-15
  3 in total

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