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Literature DB >> 6698172

Dinemorphan N-demethylation by mouse liver microsomes.

P G Gervasi, D Benetti, L Citti, M Del Monte, G Turchi.

Abstract

Dinemorphan, an antitussive drug, is N-demethylated in vitro by mouse liver microsomes with biphasic kinetics showing two apparent Km and Vmax. Moreover, dinemorphan N-demethylation is inhibited by CO, SKF-525A, metyrapone and it is specifically catalyzed by a phenobarbital-inducible form of cytochrome P-450.

Entities: Chemical Gene Species

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Year: 1984 PMID： 6698172 DOI： 10.1007/bf01963588

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

16 in total

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Authors: T OMURA; R SATO
Journal: J Biol Chem Date: 1964-07 Impact factor: 5.157

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Authors: J AXELROD
Journal: J Pharmacol Exp Ther Date: 1956-07 Impact factor: 4.030

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Authors: J R Hayes; M U Mgbodile; T C Campbell
Journal: Biochem Pharmacol Date: 1973-06-15 Impact factor: 5.858

5. Characterisation of cytochrome P-450 species in rat liver microsomes, I. Differences in the O-dealkylation of 7-ethoxycoumarin after pretreatment with phenobarbital and 3-methylcholanthrene.

Authors: V Ullrich; U Frommer; P Weber
Journal: Hoppe Seylers Z Physiol Chem Date: 1973-05

Dinemorphan N-demethylation by mouse liver microsomes.

1. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

2. Metabolic N- and O-demethylation of morphine- and morphinan-type analgesics.

3. The enzymatic N-demethylation of narcotic drugs.

4. Dependence of K m and V max on substrate concentration for rat hepatic microsomal ethylmorphine N-demethylase.

5. Characterisation of cytochrome P-450 species in rat liver microsomes, I. Differences in the O-dealkylation of 7-ethoxycoumarin after pretreatment with phenobarbital and 3-methylcholanthrene.

6. Aminopyrine demethylase. Kinetic evidence for multiple microsomal activities.

7. Product inhibition during the hepatic microsomal N-demethylation of aminopyrine in the rat.

8. Species differences in stimulation of intestinal and hepatic microsomal mixed-function oxidase enzymes.

9. Comparative pharmacology of levorphan, racemorphan and dextrorphan and related methyl ethers.

10. The metabolism of 1,3-cyclohexadiene by liver microsomal mono-oxygenase.