Literature DB >> 206967

Adrenocorticotropin in rat brain: immunocytochemical localization in cells and axons.

S J Watson, C W Richard, J D Barchas.   

Abstract

By means of antiserum (purified by affinity chromatography) directed against adrenocorticotropin (ACTH) 11-24, cell bodies and beaded axons were visualized in rat brain. The ACTH-like immunoreactivity (ACTH-LI) was primarily located in the hypothalamus (cells and axons). Fibers were scattered throughout thalamus, amygdala, periaqueductal gray area, and reticular formation. There was no change in the distribution of ACTH-LI in rats that had been subjected to hypophysectomy. This distribution of ACTH-LI parallels that of beta-lipotropin and is altered by specific lesions in a similar fashion. The presence of ACTH-LI in cells and beaded axons in brain raises the possibility that it is a neuroregulator functioning as a neurotransmitter, neuromodulator, or neurohormone.

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Year:  1978        PMID： 206967     DOI： 10.1126/science.206967

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  32 in total

1.  Localization of ACTH in the human hypothalamus.

Authors:  G Pelletier; L Désy
Journal:  Cell Tissue Res       Date:  1979-02-28       Impact factor: 5.249

2.  Immunoreactivity for beta-endorphin in LH-RH neurons of the fetal human hypothalamus.

Authors:  J Leonardelli; G Tramu
Journal:  Cell Tissue Res       Date:  1979       Impact factor: 5.249

3.  Corticotropin-like immunoreactivity in the brain of intact, hypophysectomized, cortisol- and metopirone-treated eels. Comparison with changes in pituitary corticotropes and brain corticotropin-releasing factor.

Authors:  M Olivereau; J M Olivereau
Journal:  Cell Tissue Res       Date:  1991-09       Impact factor: 5.249

4.  Leucine-enkephalin-like immunoreactive fibers in the medial preoptic area of the rat: their distribution and origin.

Authors:  M Yamano; M Tohyama; S Shiosaka; Y Shiotani; S Inagaki; S Kito
Journal:  Exp Brain Res       Date:  1985       Impact factor: 1.972

5.  Comparative investigations on the actions of ACTH1-24, somatostatin, neurotensin, substance P and vasopressin on locus coeruleus neuronal activity in vitro.

Authors:  H R Olpe; M W Steinmann; M F Pozza; H L Haas
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-10       Impact factor: 3.000

6.  Pro-dynorphin peptides are found in the same neurons throughout rat brain: immunocytochemical study.

Authors:  S J Watson; H Khachaturian; L Taylor; W Fischli; A Goldstein; H Akil
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

7.  Dynorphin immunocytochemical localization in brain and peripheral nervous system: preliminary studies.

Authors:  S J Watson; H Akil; V E Ghazarossian; A Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205

8.  Appearance of beta-endorphin-like immunoreactivity in human ventricular cerebrospinal fluid upon analgesic electrical stimulation.

Authors:  H Akil; D E Richardson; J D Barchas; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

Review 9.  Mechanism of action of melanocortin peptides. Possible role in astrocyte regulation.

Authors:  M Zohar; Y Salomon
Journal:  J Mol Neurosci       Date:  1993       Impact factor: 3.444

10.  Immunocytochemical localization of enkephalin in the lateral septum of the guinea-pig brain. A light- and electron-microscopic study.

Authors:  J C Beauvillain; P Poulain; G Tramu
Journal:  Cell Tissue Res       Date:  1983       Impact factor: 5.249
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