Literature DB >> 7359084

Serological and biochemical identification of hybrid Ia antigens.

W P Lafuse, J F McCormick, C S David.   

Abstract

Ia specificities 22 and 23 were found to be determinants on hybrid Ia molecules by serological and biochemical studies. Lipopolysaccharide-stimulated splenic lymphocytes from (B10 X B10.D2)F1 expressed Ia.22 although both the parents were negative. Similarly [D2.GD X B10.A(5R)]F1 cells expressed Ia.23, whereas D2.GD and B10.A(5R) lacked it. Ia.22 can be generated by gene complementation of Ak-Ek, Ab-Ed, Ab-Ek, As-Ed, and As-Ek, whereas Ia.23 can be generated by Ad-Ed, Ad-Ek, and Ad-Ep. Other possible complementing combinations are under study. The role of Ia.22 and 23 in mixed lymphocyte reactions and immune responses are discussed.

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Year:  1980        PMID： 7359084      PMCID： PMC2185812          DOI： 10.1084/jem.151.3.709

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  10 in total

1.  Serologic and biochemical studies of the Ia system of the mouse H-2 gene complex. Further evidence for I-C subregion.

Authors:  C S David; S E Cullen; D B Murphy
Journal:  J Immunol       Date:  1975-04       Impact factor: 5.422

2.  Serological and functional evidence for further subdivision of the I regions of the H-2 gene complex.

Authors:  D C Shreffler; C S David; S E Cullen; J A Frelinger; J E Niederhuber
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1977

3.  Murine Ia antigens: identification and mapping of Ia.23 and further definition of the I-E subregion.

Authors:  C S David; S E Cullen
Journal:  J Immunol       Date:  1978-05       Impact factor: 5.422

4.  In vitro secondary mixed leukocyte reaction (MLR). II. Interaction MLR determinants expressed by F1 cells.

Authors:  C G Fathman; M Nabholz
Journal:  Eur J Immunol       Date:  1977-06       Impact factor: 5.532

5.  An improved method for isolation of H-2 and Ia alloantigens with immunoprecipitation induced by protein A-bearing staphylococci.

Authors:  S E Cullen; B D Schwartz
Journal:  J Immunol       Date:  1976-07       Impact factor: 5.422

6.  New lymphocyte antigen system (Lna) controlled by the Ir region of the mouse H-2 complex.

Authors:  C S David; D C Shreffler; J A Frelinger
Journal:  Proc Natl Acad Sci U S A       Date:  1973-09       Impact factor: 11.205

7.  Two-gene control of the expression of a murine Ia antigen.

Authors:  P P Jones; D B Murphy; H O McDevitt
Journal:  J Exp Med       Date:  1978-10-01       Impact factor: 14.307

8.  Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion.

Authors:  R G Cook; E S Vitetta; J W Uhr; J D Capra
Journal:  J Exp Med       Date:  1979-04-01       Impact factor: 14.307

9.  Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells.

Authors:  C David; T Meo; J McCormick; D Shreffler
Journal:  J Exp Med       Date:  1976-01-01       Impact factor: 14.307

10.  Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.

Authors:  J A Frelinger; J E Neiderhuber; C S David; D C Shreffler
Journal:  J Exp Med       Date:  1974-11-01       Impact factor: 14.307
  10 in total
  22 in total

1.  Cotransfer of the Ed alpha and Ad beta genes into L cells results in the surface expression of a functional mixed-isotype Ia molecule.

Authors:  B Malissen; N Shastri; M Pierres; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

2.  Hybrid (combinatorial) Ia specificities: gene complementations to generate Ia.22.

Authors:  W P Lafuse; J F McCormick; P S Corser; C S David
Journal:  Immunogenetics       Date:  1981       Impact factor: 2.846

3.  Inhibition of secondary mouse mixed lymphocyte reaction by anti-Ia sera.

Authors:  M Pla; M Colombani; J Colombani
Journal:  Immunogenetics       Date:  1981       Impact factor: 2.846

4.  Serological cross-reactivity between products of different Ia loci.

Authors:  P A Lowry; D B Murphy
Journal:  Immunogenetics       Date:  1981       Impact factor: 2.846

5.  Antigen-presenting cells that induce anti-H-2K T-cell responses: differences in stimulator-cell requirements for induction of proliferation and cell-mediated lympholysis.

Authors:  M Pimsler; J A Trial; J Forman
Journal:  Immunogenetics       Date:  1981       Impact factor: 2.846

6.  Generation of cytotoxic T lymphocytes by the H-2-encoded E molecules.

Authors:  A Juretić; Z A Nagy; J Klein
Journal:  Immunogenetics       Date:  1981       Impact factor: 2.846

7.  Identity of molecules bearing murine Ia alloantigenic specificities Ia.7 and Ia.22: evidence for a single type of I-E molecule in homozygotes.

Authors:  S E Cullen; D C Shreffler; C S Kindle; C S David
Journal:  Immunogenetics       Date:  1980       Impact factor: 2.846

8.  Genetic control of T-cell proliferative responses to poly(glu40ala60) and poly(glu51lys34tyr15): subregion-specific inhibition of the responses with monoclonal Ia antibodies.

Authors:  C N Baxevanis; D Wernet; Z A Nagy; P H Maurer; J Klein
Journal:  Immunogenetics       Date:  1980       Impact factor: 2.846

9.  Murine T cell Ia antigens: specificity Iat.46 maps in I-J to I-E chromosomal segment of H-2 complex.

Authors:  C E Hayes; J M Maier
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

10.  Reconstitution of Ir genes, Ia antigens, and mixed lymphocyte reaction determinants by gene complementation.

Authors:  C G Fathman; M Kimoto; R Melvold; C S David
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205
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