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Literature DB >> 70357

In vitro secondary mixed leukocyte reaction (MLR). II. Interaction MLR determinants expressed by F1 cells.

Abstract

T cells from strain A primed in vitro to (C57BL/6 x A/JF1 [(B6 x A)F1] cells respond better to restimulation by (B6 x A)F1 than by B6 or a 1:1 mixture of A and B6 cells. The increase in the response to F1 cells is specific and due to MLR determinants present on (B6 x A)F1 cells but not on either of the parental cell types. (B6 x A)F1 cells express more than one F1-specific MLR determinant, and this expression is dependent upon products of alleles of at least two loci within the major histocompatibility complex (MHC). Responsiveness to these F1-MLR determinants is apparently controlled by more than one locus within the MHC.

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Epitopes

Year: 1977 PMID： 70357 DOI： 10.1002/eji.1830070609

Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532

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Cited

20 in total

1. Crossreactive mixed lymphocyte reaction determinants recognized by cloned alloreactive T cells.

Authors: C G Fathman; H Hengartner
Journal: Proc Natl Acad Sci U S A Date: 1979-11 Impact factor: 11.205

2. Human allospecific TLCs generated against HLA antigens associated with DR1 through DRw8. III. Family segregation analyses.

Authors: S Rosen-Bronson; A H Johnson; R J Hartzman; D D Eckels
Journal: Immunogenetics Date: 1988 Impact factor: 2.846

8. Quantitative variation in H-2-antigen expression. II. Evidence for a dominance pattern in H-2K and H-2D expression in F1 hybrid mice.

Authors: H C O'Neill
Journal: Immunogenetics Date: 1980 Impact factor: 2.846

9. Alterations in the expression of Ia antigens in F1 hybrid mice.

Authors: M S Sandrin; G H Tobias; I F McKenzie; G J Hämmerling
Journal: Immunogenetics Date: 1981-12 Impact factor: 2.846

10. Restricted helper function of F1 hybrid T cells positively selected to heterologous erythrocytes in irradiated parental strain mice. II. Evidence for restrictions affecting helper cell induction and T-B collaboration, both mapping to the K-end of the H-2 complex.

Authors: J Sprent
Journal: J Exp Med Date: 1978-04-01 Impact factor: 14.307

In vitro secondary mixed leukocyte reaction (MLR). II. Interaction MLR determinants expressed by F1 cells.

1. Crossreactive mixed lymphocyte reaction determinants recognized by cloned alloreactive T cells.

2. Human allospecific TLCs generated against HLA antigens associated with DR1 through DRw8. III. Family segregation analyses.

3. Clones of alloreactive T cells. I. A. unique homozygous MLR-stimulating determinant present on B6 stimulators.

4. Hybrid (combinatorial) Ia specificities: gene complementations to generate Ia.22.

5. Fine specificity of a proliferating T-cell clone activated by a conformational determinant of the I-Ek molecule.

6. Functional similarities of AeE alpha Ia molecules as determined by analysis with T-cell clones.

7. Expression of the I-E target antigen for T-cell killing requires two genes.

8. Quantitative variation in H-2-antigen expression. II. Evidence for a dominance pattern in H-2K and H-2D expression in F1 hybrid mice.

9. Alterations in the expression of Ia antigens in F1 hybrid mice.

10. Restricted helper function of F1 hybrid T cells positively selected to heterologous erythrocytes in irradiated parental strain mice. II. Evidence for restrictions affecting helper cell induction and T-B collaboration, both mapping to the K-end of the H-2 complex.