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Literature DB >> 429967

Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion.

R G Cook, E S Vitetta, J W Uhr, J D Capra.

Abstract

The E/C alpha- and beta-subunits of intra-I-region recombinants were analyzed for primary structural variation by comparative tryptic peptide mapping. The E/C alpha-polypeptides from B10.A, B10.A (3R) and B10.A (5R) showed complete coincident elution of peptides; the E/C beta-chains from B10.A and 3R (or 5R) were approximately 40% different. This suggests that the structural gene for the E/C beta-polypeptide is within the I-A subregion.

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Year: 1979 PMID： 429967 PMCID： PMC2184847 DOI： 10.1084/jem.149.4.981

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

11 in total

Review 1. Studies on the protein products of murine chromosome 17:a status report.

Authors: R Cook; M C Carroll; J W Uhr; E S Vitetta; J D Capra
Journal: Transplant Proc Date: 1978-12 Impact factor: 1.066

2. Serological and functional evidence for further subdivision of the I regions of the H-2 gene complex.

Authors: D C Shreffler; C S David; S E Cullen; J A Frelinger; J E Niederhuber
Journal: Cold Spring Harb Symp Quant Biol Date: 1977

Review 3. Histocompatibility-linked immune response genes.

Authors: B Benacerraf; H O McDevitt
Journal: Science Date: 1972-01-21 Impact factor: 47.728

4. Heavy HLA-DR (Ia) antigen chain is controlled by the MHC region.

Authors: L Klareskog; L Rask; J Fohlman; P A Peterson
Journal: Nature Date: 1978-10-26 Impact factor: 49.962

5. The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.

Authors: D C Shreffler; C S David
Journal: Adv Immunol Date: 1975 Impact factor: 3.543

6. Genetics and serology of HL-A-linked human Ia antigens.

Authors: C J Barnstable; E A Jones; W F Bodmer; J G Bodmer; B Arce-Gomez; D Snary; M J Crumpton
Journal: Cold Spring Harb Symp Quant Biol Date: 1977

7. Genetic control of specific immune responses and immune suppressions by I-region genes.

Authors: B Benacerraf; M E Dorf
Journal: Cold Spring Harb Symp Quant Biol Date: 1977

8. Structural studies on the murine IA alloantigens. II. Molecular weight characterization of the products of the I-A and I-E/C subregions.

Authors: R G Cook; J W Uhr; J D Capra; E S Vitetta
Journal: J Immunol Date: 1978-12 Impact factor: 5.422

9. Identity of molecules bearing murine Ia alloantigenic specificities Ia.7 and Ia.22: evidence for a single type of I-E molecule in homozygotes.

Authors: S E Cullen; D C Shreffler; C S Kindle; C S David
Journal: Immunogenetics Date: 1980 Impact factor: 2.846

10. I-E/I-C region-associated induction of murine gamma interferon by a haplotype-restricted polyclonal T-cell mitogen derived from Mycoplasma arthritidis.

Authors: B C Cole; R N Thorpe
Journal: Infect Immun Date: 1984-01 Impact factor: 3.441

Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion.

Review 1. Studies on the protein products of murine chromosome 17:a status report.

2. Serological and functional evidence for further subdivision of the I regions of the H-2 gene complex.

Review 3. Histocompatibility-linked immune response genes.

4. Heavy HLA-DR (Ia) antigen chain is controlled by the MHC region.

5. The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.

6. Genetics and serology of HL-A-linked human Ia antigens.

7. Genetic control of specific immune responses and immune suppressions by I-region genes.

8. Structural studies on the murine IA alloantigens. II. Molecular weight characterization of the products of the I-A and I-E/C subregions.

9. Two-gene control of the expression of a murine Ia antigen.

10. Analysis of H-2 and Ia molecules by two-dimensional gel electrophoresis.

1. Identification of two Ia-like alloantigens on rabbit B lymphocytes.

2. Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system.

3. Hybrid (combinatorial) Ia specificities: gene complementations to generate Ia.22.

4. A monoclonal antibody detecting an Ia specificity mapping in the I-A or I-E subregion.

5. Functional similarities of AeE alpha Ia molecules as determined by analysis with T-cell clones.

6. Hybridoma monoclonal antibodies in the analysis of human cell surface antigens.

Review 7. Helper and suppressor T cell factors.

8. Biochemical evidence for multiple I-E Ia molecules.

9. Identity of molecules bearing murine Ia alloantigenic specificities Ia.7 and Ia.22: evidence for a single type of I-E molecule in homozygotes.

10. I-E/I-C region-associated induction of murine gamma interferon by a haplotype-restricted polyclonal T-cell mitogen derived from Mycoplasma arthritidis.