Literature DB >> 7326031

Phenylalanine metabolism in isolated rat liver cells. Effects of glucagon and diabetes.

F P Carr, C I Pogson.   

Abstract

1. Methods are described for monitoring the metabolic flux through phenylalanine hydroxylase, the tyrosine catabolic pathway and phenylalanine: pyruvate transaminase in isolated liver cell incubations. 2. The relationship between hydroxylase flux and phenylalanine concentration is sigmoidal. 3. Glucagon increases hydroxylase activity at low, near-physiological, substrate concentrations only. The hormone does not affect the rate of formation of phenylpyruvate. 4. Experimental diabetes (for 10 days) increases phenylalanine catabolism, and this is further increased by glucagon. 5. These results are discussed in the light of the known mechanisms for control of phenylalanine hydroxylase activity in vitro.

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Year:  1981        PMID： 7326031      PMCID： PMC1163314          DOI： 10.1042/bj1980655

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  41 in total

1.  DISTINCT MEDIATING SYSTEMS FOR THE TRANSPORT OF NEUTRAL AMINO ACIDS BY THE EHRLICH CELL.

Authors:  D L OXENDER; H N CHRISTENSEN
Journal:  J Biol Chem       Date:  1963-11       Impact factor: 5.157

2.  Compartmentation of free valine and its relation to protein turnover in perfused rat liver.

Authors:  G E Mortimore; K H Woodside; J E Henry
Journal:  J Biol Chem       Date:  1972-05-10       Impact factor: 5.157

3.  The stimulation of rat liver phenylalanine hydroxylase by phospholipids.

Authors:  D B Fisher; S Kaufman
Journal:  J Biol Chem       Date:  1972-04-10       Impact factor: 5.157

Review 4.  Some special kinetic problems of transport.

Authors:  H N Christensen
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1969

5.  A protein that stimulates rat liver phenylalanine hydroxylase.

Authors:  S Kaufman
Journal:  J Biol Chem       Date:  1970-09-25       Impact factor: 5.157

6.  The stimulation of rat liver phenylalanine hydroxylase by lysolecithin and -chymotrypsin.

Authors:  D B Fisher; S Kaufman
Journal:  J Biol Chem       Date:  1973-06-25       Impact factor: 5.157

7.  Free amino acids in the caiman and rat.

Authors:  J D Herbert; R A Coulson; T Hernandez
Journal:  Comp Biochem Physiol       Date:  1966-02

8.  Hydroxylation-induced migration: the NIH shift. Recent experiments reveal an unexpected and general result of enzymatic hydroxylation of aromatic compounds.

Authors:  G Guroff; J W Daly; D M Jerina; J Renson; B Witkop; S Udenfriend
Journal:  Science       Date:  1967-09-29       Impact factor: 47.728

9.  A simple radioisotope assay for phenylalanine hydroxylase.

Authors:  G Guroff; A Abramowitz
Journal:  Anal Biochem       Date:  1967-06       Impact factor: 3.365

10.  The use of deuterated phenylalanine for the elucidation of the phenylalanine-tyrosine metabolism.

Authors:  H C Curtius; J A Völlmin; K Baerlocher
Journal:  Clin Chim Acta       Date:  1972-03       Impact factor: 3.786
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  10 in total

1.  The effect of streptozotocin-induced diabetes on phenylalanine hydroxylase expression in rat liver.

Authors:  D S Taylor; H H Dahl; J F Mercer; A K Green; M J Fisher
Journal:  Biochem J       Date:  1989-11-15       Impact factor: 3.857

2.  The role of insulin in the modulation of glucagon-dependent control of phenylalanine hydroxylation in isolated liver cells.

Authors:  M J Fisher; A J Dickson; C I Pogson
Journal:  Biochem J       Date:  1987-03-15       Impact factor: 3.857

3.  Quantification of the importance of individual steps in the control of aromatic amino acid metabolism.

Authors:  M Salter; R G Knowles; C I Pogson
Journal:  Biochem J       Date:  1986-03-15       Impact factor: 3.857

4.  Effects of adrenergic agents, vasopressin and ionophore A23187, on the phosphorylation of, and flux through, phenylalanine hydroxylase in rat liver cells.

Authors:  M J Fisher; M A Santana; C I Pogson
Journal:  Biochem J       Date:  1984-04-01       Impact factor: 3.857

5.  Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus.

Authors:  R R Dighe; F J Rojas; L Birnbaumer; A J Garber
Journal:  J Clin Invest       Date:  1984-04       Impact factor: 14.808

6.  Phenylalanine hydroxylase in liver cells. Correlation of glucagon-stimulated enzyme phosphorylation with expressed activity.

Authors:  M J Fisher; C I Pogson
Journal:  Biochem J       Date:  1984-04-01       Impact factor: 3.857

7.  The metabolism of L-phenylalanine and L-tyrosine by liver cells isolated from adrenalectomized rats and from streptozotocin-diabetic rats.

Authors:  J C Stanley; M J Fisher; C I Pogson
Journal:  Biochem J       Date:  1985-05-15       Impact factor: 3.857

8.  Transport of the aromatic amino acids into isolated rat liver cells. Properties of uptake by two distinct systems.

Authors:  M Salter; R G Knowles; C I Pogson
Journal:  Biochem J       Date:  1986-01-15       Impact factor: 3.857

9.  The influence of starvation and tryptophan administration on the metabolism of phenylalanine, tyrosine and tryptophan in isolated rat liver cells.

Authors:  M Salter; J C Stanley; M J Fisher; C I Pogson
Journal:  Biochem J       Date:  1984-07-15       Impact factor: 3.857

10.  The effect of experimental diabetes on phenylalanine metabolism in isolated liver cells.

Authors:  M A Santana; M J Fisher; A J Bate; C I Pogson
Journal:  Biochem J       Date:  1985-04-01       Impact factor: 3.857
  10 in total

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