Literature DB >> 2532505

The effect of streptozotocin-induced diabetes on phenylalanine hydroxylase expression in rat liver.

D S Taylor1, H H Dahl, J F Mercer, A K Green, M J Fisher.   

Abstract

The impact of experimentally induced diabetes on the expression of rat liver phenylalanine hydroxylase has been investigated. A significant elevation in maximal enzymic activity was observed in diabetes. This was associated with significant increases in the amount of enzyme, the phenylalanine hydroxylase-specific translational activity of hepatic RNA and the abundance of phenylalanine hydroxylase-specific mRNA. These changes in phenylalanine hydroxylase expression were not observed when diabetes was controlled by daily injections of insulin. These results are discussed in relation to the hormonal control of phenylalanine hydroxylase gene expression.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2532505      PMCID： PMC1133562          DOI： 10.1042/bj2640185

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  37 in total

1.  Relationship between phosphorylation of tyrosine aminotransferase and regulation of its synthesis by cyclic AMP and hormones.

Authors:  W D Wicks; J L Su
Journal:  J Cyclic Nucleotide Res       Date:  1978-04

2.  Phenylalanine hydroxylase in cultured hepatoxytes. I. Hormonal control of enzyme levels.

Authors:  D F Haggerty; P L Young; G Popják; W H Carnes
Journal:  J Biol Chem       Date:  1973-01-10       Impact factor: 5.157

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  Hepatic enzyme activities in streptozotocin-diabetic rats before and after insulin treatment.

Authors:  A Y Chang; D I Schneider
Journal:  Diabetes       Date:  1971-02       Impact factor: 9.461

5.  Development of phenylalanine hydroxylase activity in guinea pig liver.

Authors:  H K Berry; R Cripps; K Nicholls; D McCandless; C Harper
Journal:  Biochim Biophys Acta       Date:  1971-02-28

6.  Effect of insulin on glycogen and protein synthesis in monolayer cultures of hepatocytes from normal and alloxan diabetic rats.

Authors:  P Bellemann; J R Fry; J W Bridges; W Schlote; D Mecke
Journal:  Diabetologia       Date:  1977-12       Impact factor: 10.122

7.  Studies on gluconeogenesis, protein synthesis and cyclic AMP levels in isolated hepatocytes from alloxan diabetic rats.

Authors:  S R Wagle; W R Ingebretsen; L Sampson
Journal:  Diabetologia       Date:  1975-10       Impact factor: 10.122

8.  Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP.

Authors:  E J Lewis; C A Harrington; D M Chikaraishi
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

9.  In vitro activation of rat liver phenylalanine hydroxylase by phosphorylation.

Authors:  J P Abita; S Milstien; N Chang; S Kaufman
Journal:  J Biol Chem       Date:  1976-09-10       Impact factor: 5.157

10.  The influence of streptozotocin diabetes on adrenal function in male rats.

Authors:  A F De Nicola; O Fridman; E J Del Castillo; V G Foglia
Journal:  Horm Metab Res       Date:  1976-09       Impact factor: 2.936
View more
  2 in total

1.  Identification of multiple genes in bovine retinal pericytes altered by exposure to elevated levels of glucose by using mRNA differential display.

Authors:  L P Aiello; G S Robinson; Y W Lin; Y Nishio; G L King
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-21       Impact factor: 11.205

2.  Impaired hepatic apolipoprotein B and E translation in streptozotocin diabetic rats.

Authors:  J D Sparks; R Zolfaghari; C E Sparks; H C Smith; E A Fisher
Journal:  J Clin Invest       Date:  1992-05       Impact factor: 14.808
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.