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Literature DB >> 7325966

The definitive identification of the lignans trans-2,3-bis(3-hydroxybenzyl)-gamma-butyrolactone and 2,3-bis(3-hydroxybenzyl)butane-1,4-diol in human and animal urine.

K D Setchell, A M Lawson, E Conway, N F Taylor, D N Kirk, G Cooley, R D Farrant, S Wynn, M Axelson.

Abstract

The definitive identification of the first lignans to be found in humans and animals is described. Gas chromatography--mass spectrometry, n.m.r. spectroscopy, i.r. spectroscopy and chemical techniques were employed to establish the structures of two lignans as trans-2,3-bis(3-hydroxybenzyl)-gamma-butyrolactone and 2,3-bis(3-hydroxybenzyl)butane-1,4-diol. Both compounds are essetially racemic. Evidence was also found for several methoxy analogues of these lignans in the vervet monkey.

Entities: Chemical Species

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Year: 1981 PMID： 7325966 PMCID： PMC1163145 DOI： 10.1042/bj1970447

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

11 in total

1. The multicomponent analysis of conjugates of neutral steroids in urine by lipophilic ion exchange chromatography and computerised gas chromatography-mass spectrometry.

Authors: K D Setchell; B Almé; M Axelson; J Sjövall
Journal: J Steroid Biochem Date: 1976-08 Impact factor: 4.292

2. Analysis of steroids by high resolution gas-liquid chromatography. I. Preparation of apolar columns.

Authors: G A Rutten; J A Luyten
Journal: J Chromatogr Date: 1972-12-20

3. The group separation of plasma and urinary steroids by column chromatography on sephadex LH-20.

Authors: K D Setchell; C H Shackleton
Journal: Clin Chim Acta Date: 1973-09-14 Impact factor: 3.786

4. Analysis of steroids by off-line computerized gas chromatography-mass spectrometry.

Authors: R Reimendal; J Sjövall
Journal: Anal Chem Date: 1972-01 Impact factor: 6.986

5. Source of aromatic affinity to "Sephadex" dextran gels.

Authors: H Determann; I Walter
Journal: Nature Date: 1968-08-10 Impact factor: 49.962

6. Conjugation of lignans in human urine.

Authors: M Axelson; K D Setchell
Journal: FEBS Lett Date: 1980-12-15 Impact factor: 4.124

7. Steroid excretion during the reporductive cycle and in pregnanacy of the vervet monkey (Cercopithecus aethiopus pygerythrus).

Authors: K D Setchell; R Bull; H Adlercreutz
Journal: J Steroid Biochem Date: 1980-01 Impact factor: 4.292

8. Use of Sep-pak cartridges for urinary steroid extraction: evaluation of the method for use prior to gas chromatographic analysis.

Authors: C H Shackleton; J O Whitney
Journal: Clin Chim Acta Date: 1980-11-06 Impact factor: 3.786

Review 4. Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets.

Authors: S Franklyn De Silva; Jane Alcorn
Journal: Pharmaceuticals (Basel) Date: 2019-05-05

4 in total

The definitive identification of the lignans trans-2,3-bis(3-hydroxybenzyl)-gamma-butyrolactone and 2,3-bis(3-hydroxybenzyl)butane-1,4-diol in human and animal urine.

1. The multicomponent analysis of conjugates of neutral steroids in urine by lipophilic ion exchange chromatography and computerised gas chromatography-mass spectrometry.

2. Analysis of steroids by high resolution gas-liquid chromatography. I. Preparation of apolar columns.

3. The group separation of plasma and urinary steroids by column chromatography on sephadex LH-20.

4. Analysis of steroids by off-line computerized gas chromatography-mass spectrometry.

5. Source of aromatic affinity to "Sephadex" dextran gels.

6. Conjugation of lignans in human urine.

7. Steroid excretion during the reporductive cycle and in pregnanacy of the vervet monkey (Cercopithecus aethiopus pygerythrus).

8. Use of Sep-pak cartridges for urinary steroid extraction: evaluation of the method for use prior to gas chromatographic analysis.

9. Lignans in man and in animal species.

10. Excretion, isolation and structure of a new phenolic constituent of female urine.

Review 1. Equol: history, chemistry, and formation.

2. The identification of the weak oestrogen equol [7-hydroxy-3-(4'-hydroxyphenyl)chroman] in human urine.

3. Purification of a new peroxidase catalysing the formation of lignan-type compounds.

Review 4. Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets.