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Literature DB >> 7301595

Z-DNA conformation of N-2-acetylaminofluorene modified poly(dG-dC).poly(dG-dC) determined by reactivity with anti cytidine antibodies and minimized potential energy calculations.

R M Santella, D Grunberger, S Broyde, B E Hingerty.

Abstract

The conformation of poly(dG-dC).poly(dG-dC), poly(dG).poly(dC), and calf thymus DNA modified with N-acetoxy-N-2-acetylaminofluorene (N-acetoxy-AAF) was examined by extent of reaction with anti cytidine antibodies. In contrast to modified poly(dG).poly(dC0 and DNA, modified poly(dG-dC).poly (dG-dC) failed to react with the antibodies indicating that the base pairing in this polymer is intact. This in consistent with induction of the Z-DNA conformation in AAF modified poly(dG-dC).poly(dG-dC). Using minimized potential energy calculations on the dCpdG-AAF dimer as a model for the modified polymer, it is shown that the proposed Z-DNA conformation is energetically stable. A model is proposed for an AAF modified tetramer, dGpdCpdGpdC, in which the AAF is external to the Z-DNA duplex.

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Year: 1981 PMID： 7301595 PMCID： PMC327532 DOI： 10.1093/nar/9.20.5459

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

17 in total

1. In vitro recognition of carcinogen-induced local denaturation sites native DNA by S1 endonuclease from Aspergillus oryzae.

Authors: R P Fuchs
Journal: Nature Date: 1975-09-11 Impact factor: 49.962

2. Structure of the 3' hairpin termini of four rodent parvovirus genomes: nucleotide sequence homology at origins of DNA replication.

Authors: C R Astell; M Smith; M B Chow; D C Ward
Journal: Cell Date: 1979-07 Impact factor: 41.582

3. Polymorphism of a synthetic DNA in solution.

Authors: F M Pohl
Journal: Nature Date: 1976-03-25 Impact factor: 49.962

4. Differential excision from DNA of the C-8 and N2 guanosine adducts of N-acetyl-2-aminofluorene by single strand-specific endonucleases.

Authors: H Yamasaki; P Pulkrabek; D Grunberger; I B Weinstein
Journal: Cancer Res Date: 1977-10 Impact factor: 12.701

5. Detection of carcinogen-DNA adducts by radiommunoassay.

Authors: M C Poirier; S H Yuspa; I B Weinstein; S Blobstein
Journal: Nature Date: 1977-11-10 Impact factor: 49.962

6. Dynamic structure of DNA modified with the carcinogen N-acetoxy-n-2-acetylaminofluorene.

Authors: R P Fuchs; M P Daune
Journal: Biochemistry Date: 1974-10-08 Impact factor: 3.162

7. Conformational analysis of the sugar ring in nucleosides and nucleotides. A new description using the concept of pseudorotation.

Authors: C Altona; M Sundaralingam
Journal: J Am Chem Soc Date: 1972-11-15 Impact factor: 15.419

8. Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).

Authors: F M Pohl; T M Jovin
Journal: J Mol Biol Date: 1972-06-28 Impact factor: 5.469

9. Temperature-induced perturbations in the circular dichroic spectrum of the synthetic polymer poly[d(G-C)].

Authors: V Narasimhan; A M Bryan
Journal: Biochim Biophys Acta Date: 1976-07-16

10. Induction of the Z conformation in poly(dG-dC).poly(dG-dC) by binding of N-2-acetylaminofluorene to guanine residues.

Authors: R M Santella; D Grunberger; I B Weinstein; A Rich
Journal: Proc Natl Acad Sci U S A Date: 1981-03 Impact factor: 11.205

15 in total

1. Z-DNA-forming sequences are spontaneous deletion hot spots.

Authors: A M Freund; M Bichara; R P Fuchs
Journal: Proc Natl Acad Sci U S A Date: 1989-10 Impact factor: 11.205

2. uvrC gene function has no specific role in repair of N-2-aminofluorene adducts.

Authors: M Bichara; R P Fuchs
Journal: J Bacteriol Date: 1987-01 Impact factor: 3.490

3. Base specific binding of deoxyguanylate and deoxycytidylate antibodies to double stranded DNA.

Authors: A Jacob; T M Jacob
Journal: Nucleic Acids Res Date: 1982-10-25 Impact factor: 16.971

4. Studies on the conformation and dynamics of the C8-substituted guanine adduct of the carcinogen acetylaminofluorene; model for a possible Z-DNA modified structure.

Authors: S Neidle; R Kuroda; S Broyde; B E Hingerty; R A Levine; D W Miller; F E Evans
Journal: Nucleic Acids Res Date: 1984-11-12 Impact factor: 16.971

5. AAF linked to the guanine amino group: a B-Z junction.

Authors: B Hingerty; S Broyde
Journal: Nucleic Acids Res Date: 1983-05-25 Impact factor: 16.971

6. Circular dichroism of poly(dG-dC) modified by the carcinogens N-methyl-4-aminoazobenzene or 4-aminobiphenyl.

Authors: P A Abuaf; F F Kadlubar; D Grunberger
Journal: Nucleic Acids Res Date: 1987-09-11 Impact factor: 16.971

7. Conformations of poly(dG-dC).poly(dG-dC) modified by the O-acetyl derivative of the carcinogen 4-hydroxyaminoquinoline 1-oxide.

Authors: B Bailleul; S Galiègue-Zouitina; M H Loucheux-Lefebvre
Journal: Nucleic Acids Res Date: 1984-10-25 Impact factor: 16.971

8. Conformational changes induced in DNA by the in vitro reaction with the mutagenic amine: 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido (1,2-a: 3', 2'-d) imidazole.

Authors: E Hébert; B Loukakou; G Saint-Ruf; M Leng
Journal: Nucleic Acids Res Date: 1984-11-26 Impact factor: 16.971

9. The ultimate carcinogen of 4-nitroquinoline 1-oxide does not react with Z-DNA and hyperreacts with B-Z junctions.

Authors: C Rodolfo; A Lanza; S Tornaletti; G Fronza; A M Pedrini
Journal: Nucleic Acids Res Date: 1994-02-11 Impact factor: 16.971

10. Effect of acetylated and deacetylated 2-aminofluorene adducts on in vitro DNA synthesis.

Authors: P D Moore; S D Rabkin; A L Osborn; C M King; B S Strauss
Journal: Proc Natl Acad Sci U S A Date: 1982-12 Impact factor: 11.205