Literature DB >> 4404668

Properties of purified pneumococcal hemolysin.

M K Johnson.   

Abstract

With a purified preparation of pneumococcal hemolysin, a sigmoid relationship was found to exist between lysin concentration and hemolytic activity. Hemolysis was inhibited by a high ratio of erythrocytes to lysin, suggesting a multi-hit mechanism of action. Reaction rate decreased rapidly with time, possibly due to competition between ghosts and unlysed erythrocytes for fixation of lysin. The effects of pH and various agents on the processes of lysin adsorption and hemoglobin release were determined. The pneumococcal preparation did not possess nicotinamide adenine dinucleotide glycohydrolase activity.

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Year:  1972        PMID： 4404668      PMCID： PMC422606          DOI： 10.1128/iai.6.5.755-760.1972

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  8 in total

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Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

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Authors:  N O KAPLAN; S P COLOWICK; A NASON
Journal:  J Biol Chem       Date:  1951-08       Impact factor: 5.157

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Authors:  F J Fehrenbach
Journal:  Eur J Biochem       Date:  1971-01-01

4.  Purification of pneumolysin.

Authors:  C N Shumway; S J Klebanoff
Journal:  Infect Immun       Date:  1971-10       Impact factor: 3.441

5.  Identity of streptolysin-O and NAD-glycohydrolase (EC 3.2.2.5).

Authors:  F J Fehrenbach
Journal:  Z Naturforsch B       Date:  1971-12       Impact factor: 1.047

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Journal:  Ann Inst Pasteur (Paris)       Date:  1968-07

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Authors:  T D Oberley; J L Duncan
Journal:  Infect Immun       Date:  1971-12       Impact factor: 3.441

8.  A streptococcal enzyme that acts specifically upon diphosphopyridine nucleotide: characterization of the enzyme and its separation from streptolysin O.

Authors:  A S CARLSON; A KELLNER; A W BERNHEIMER; E B FREEMAN
Journal:  J Exp Med       Date:  1957-07-01       Impact factor: 14.307
  8 in total
  22 in total

1.  Purification and characterization of a vulnificolysin-like cytolysin produced by Vibrio tubiashii.

Authors:  M H Kothary; R B Delston; S K Curtis; B A McCardell; B D Tall
Journal:  Appl Environ Microbiol       Date:  2001-08       Impact factor: 4.792

2.  Intermedilysin, a novel cytotoxin specific for human cells secreted by Streptococcus intermedius UNS46 isolated from a human liver abscess.

Authors:  H Nagamune; C Ohnishi; A Katsuura; K Fushitani; R A Whiley; A Tsuji; Y Matsuda
Journal:  Infect Immun       Date:  1996-08       Impact factor: 3.441

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Authors:  K Kanclerski; R Möllby
Journal:  J Clin Microbiol       Date:  1987-02       Impact factor: 5.948

4.  Effect of tetanolysin on platelets and lysosomes.

Authors:  C B Cox; C Hardegree; R Fornwald
Journal:  Infect Immun       Date:  1974-04       Impact factor: 3.441

5.  Physical separation of streptococcal nicotinamide adenine dinucleotide glycohydrolase from streptolysin O.

Authors:  S Shany; P S Grushoff; A W Bernheimer
Journal:  Infect Immun       Date:  1973-05       Impact factor: 3.441

6.  Characterization of a recombinant pneumolysin and its use as a protein carrier for pneumococcal type 18C conjugate vaccines.

Authors:  J Kuo; M Douglas; H K Ree; A A Lindberg
Journal:  Infect Immun       Date:  1995-07       Impact factor: 3.441

7.  Amino acids in pneumolysin important for hemolytic activity identified by random mutagenesis.

Authors:  J Hill; P W Andrew; T J Mitchell
Journal:  Infect Immun       Date:  1994-02       Impact factor: 3.441

8.  Identification of hydrogen peroxide as a Streptococcus pneumoniae toxin for rat alveolar epithelial cells.

Authors:  P G Duane; J B Rubins; H R Weisel; E N Janoff
Journal:  Infect Immun       Date:  1993-10       Impact factor: 3.441

9.  Cation flux studies of the lesion induced in human erythrocyte membranes by the thermostable direct hemolysin of Vibrio parahaemolyticus.

Authors:  J S Huntley; A C Hall; V Sathyamoorthy; R H Hall
Journal:  Infect Immun       Date:  1993-10       Impact factor: 3.441

10.  Diagnosis of pneumococcal pneumonia by enzyme-linked immunosorbent assay of antibodies to pneumococcal hemolysin (pneumolysin).

Authors:  M Kalin; K Kanclerski; M Granström; R Möllby
Journal:  J Clin Microbiol       Date:  1987-02       Impact factor: 5.948
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