Literature DB >> 2889665

Modulation of granulocyte functions by bacterial exotoxin and endotoxins.

K D Bremm1, W König, M Thelestam, J E Alouf.   

Abstract

The modulation of granulocyte functions by bacterial exotoxins (Streptolysin O, alveolysin, theta toxin) and endotoxins from salmonella and lipid A is described here. Incubation of polymorphonuclear granulocytes with thiol-activated toxins resulted in an increased leukotriene generation. Toxin-pretreated PMNs revealed an increased omega oxidation of LTB4, which may explain why toxin-stimulated cells release more LTC4 than LTB4. Furthermore, toxin-pretreated PMNs showed a decreased leukotriene generation on subsequent stimulation with the Ca-ionophore A 23187 or opsonized zymosan.

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Year:  1987        PMID： 2889665      PMCID： PMC1454132     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  38 in total

1.  Release of eosinophil chemotactic factor from human polymorphonuclear neutrophils by calcium ionophore A23187 and phagocytosis.

Authors:  B M Gzarnetzki; W Konig; L M Lichtenstein
Journal:  Nature       Date:  1975-12-25       Impact factor: 49.962

2.  Eosinophil chemotactic factor (ECF). II. Release from human polymorphonuclear leukocytes during phagocytosis.

Authors:  W König; B M Czarnetzki; L M Lichtenstein
Journal:  J Immunol       Date:  1976-07       Impact factor: 5.422

3.  Interaction of streptolysin O from Streptococcus pyogenes and theta-toxin from Clostridium perfringens with human fibroblasts.

Authors:  M Thelestam; R Möllby
Journal:  Infect Immun       Date:  1980-09       Impact factor: 3.441

4.  Studies on human polymorphonuclear leukocyte enzymes. I. Assay of acid hydrolases and other enzymes.

Authors:  J L Avila; J Convit
Journal:  Biochim Biophys Acta       Date:  1973-02-15

5.  Effects of pneumolysin on human polymorphonuclear leukocytes and platelets.

Authors:  M K Johnson; D Boese-Marrazzo; W A Pierce
Journal:  Infect Immun       Date:  1981-10       Impact factor: 3.441

6.  Metabolism of leukotriene B4 by polymorphonuclear granulocytes of severely burned patients.

Authors:  J Brom; W König; M Köller; W Gross-Weege; G Erbs; F Müller
Journal:  Prostaglandins Leukot Med       Date:  1987-05

7.  Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid.

Authors:  J Y Vanderhoek; R W Bryant; J M Bailey
Journal:  J Biol Chem       Date:  1980-11-10       Impact factor: 5.157

8.  Leukotriene B4: a mediator of vascular permeability.

Authors:  M A Bray; F M Cunningham; A W Ford-Hutchinson; M J Smith
Journal:  Br J Pharmacol       Date:  1981-03       Impact factor: 8.739

9.  Biochemical and morphological characterization of azurophil and specific granules of human neutrophilic polymorphonuclear leukocytes.

Authors:  U Bretz; M Baggiolini
Journal:  J Cell Biol       Date:  1974-10       Impact factor: 10.539

10.  Resolution of granules from rabbit heterophil leukocytes into distinct populations by zonal sedimentation.

Authors:  M Baggiolini; J G Hirsch; C De Duve
Journal:  J Cell Biol       Date:  1969-02       Impact factor: 10.539
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  7 in total

Review 1.  Microbial pathogenicity and host defense in burned patients--the role of inflammatory mediators.

Authors:  W König; B Schlüter; J Scheffer; M Köller
Journal:  Infection       Date:  1992       Impact factor: 3.553

2.  Concurrent lipopolysaccharide enhances chemotactic response of human polymorphonuclear leukocytes to bacterial chemotaxin.

Authors:  H R Creamer; N Hunter; W W Bullock; W L Gabler
Journal:  Inflammation       Date:  1991-06       Impact factor: 4.092

3.  Effect of Staphylococcus aureus delta-toxin on human granulocyte functions and platelet-activating-factor metabolism.

Authors:  S Kasimir; W Schönfeld; J E Alouf; W König
Journal:  Infect Immun       Date:  1990-06       Impact factor: 3.441

4.  Induction of inflammatory mediators (histamine and leukotrienes) from rat peritoneal mast cells and human granulocytes by Pseudomonas aeruginosa strains from burn patients.

Authors:  U Bergmann; J Scheffer; M Köller; W Schönfeld; G Erbs; F E Müller; W König
Journal:  Infect Immun       Date:  1989-07       Impact factor: 3.441

5.  GTP-binding proteins are involved in the modulated activity of human neutrophils treated with the Panton-Valentine leukocidin from Staphylococcus aureus.

Authors:  T Hensler; M Köller; G Prévost; Y Piémont; W König
Journal:  Infect Immun       Date:  1994-12       Impact factor: 3.441

6.  Leukotriene generation and metabolism in isolated human lung macrophages.

Authors:  W Schönfeld; B Schlüter; R Hilger; W König
Journal:  Immunology       Date:  1988-12       Impact factor: 7.397

7.  Effects of adhesins from mannose-resistant Escherichia coli on mediator release from human lymphocytes, monocytes, and basophils and from polymorphonuclear granulocytes.

Authors:  Y Ventur; J Scheffer; J Hacker; W Goebel; W König
Journal:  Infect Immun       Date:  1990-06       Impact factor: 3.441
  7 in total

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