| Literature DB >> 7266675 |
M Eigen, R Winkler-Oswatitsch.
Abstract
The theory of self-reproductive molecular systems involves the consequence that translation must have started from a selected distribution of RNA molecules, that comprised GC-rich sequences of a length less than 100 nucleotides. This implies a joint function of messenger and adaptor, which both had to be recruited from the same mutant distribution. The reconstruction of tRNA precursors yields such a molecule showing some reverberation of a codon pattern GNC. These findings suggest that tRNA has been the earliest component of the translation machinery.Mesh:
Substances:
Year: 1981 PMID: 7266675 DOI: 10.1007/BF01047470
Source DB: PubMed Journal: Naturwissenschaften ISSN: 0028-1042