Literature DB >> 279919

Origin of the genetic code: a testable hypothesis based on tRNA structure, sequence, and kinetic proofreading.

J J Hopfield.   

Abstract

We hypothesize that the origin of the genetic code is associated with the structure of the tRNA that existed in primal cells. The sequences of modern tRNA contain correlations which can be understood as "fossil" evidence of the secondary structure of primal tRNA. Kinetic proofreading through diffusion can amplify a low level of intrinsic selectivity of tRNA for its amino acid. Experimental tests of the theory are suggested.

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Year:  1978        PMID： 279919      PMCID： PMC336109          DOI： 10.1073/pnas.75.9.4334

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

1.  Organic compound synthesis on the primitive earth.

Authors:  S L MILLER; H C UREY
Journal:  Science       Date:  1959-07-31       Impact factor: 47.728

2.  Cell-free systems of polypeptide biosynthesis and approaches to the evolution of translation apparatus.

Authors:  A S Spirin
Journal:  Orig Life       Date:  1976-04

3.  A cybernetic approach to the origin of the genetic coding mechanism. I. Methodological principles.

Authors:  V A Ratner; A G Batchinsky
Journal:  Orig Life       Date:  1976-08

4.  A speculation on the origin of protein synthesis.

Authors:  F H Crick; S Brenner; A Klug; G Pieczenik
Journal:  Orig Life       Date:  1976-12

5.  The rates of evolution in some ribosomal components.

Authors:  H Hori; K Higo; S Osawa
Journal:  J Mol Evol       Date:  1977-05-13       Impact factor: 2.395

Review 6.  The mechanism of aminoacylation of transfer RNA.

Authors:  R B Loftfield
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1972

7.  The modification of nucleosides and nucleotides. X. Evidence for the important role of inosine residue in codon recognition of yeast alanine tRNA.

Authors:  M Yoshida; Y Kaziro; T Ukita
Journal:  Biochim Biophys Acta       Date:  1968-10-29

8.  Studies on 5 s RNA conformation by partial ribonuclease hydrolysis.

Authors:  B R Jordan
Journal:  J Mol Biol       Date:  1971-02-14       Impact factor: 5.469

9.  Is there a physical chemical basis for the present genetic code?

Authors:  M Raszka; M Mandel
Journal:  J Mol Evol       Date:  1972-12-29       Impact factor: 2.395

10.  Molecular mechanics of translation: a reciprocating ratchet mechanism.

Authors:  C Woese
Journal:  Nature       Date:  1970-05-30       Impact factor: 49.962
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  45 in total

Review 1.  The early phases of genetic code origin: conjectures on the evolution of coded catalysis.

Authors:  Massimo Di Giulio
Journal:  Orig Life Evol Biosph       Date:  2003-10       Impact factor: 1.950

2.  A new classification scheme of the genetic code.

Authors:  Thomas Wilhelm; Svetlana Nikolajewa
Journal:  J Mol Evol       Date:  2004-11       Impact factor: 2.395

3.  Origin of genetically encoded protein synthesis: a model based on selection for RNA peptidation.

Authors:  J T Wong
Journal:  Orig Life Evol Biosph       Date:  1991       Impact factor: 1.950

4.  Self-association of adenine-dependent hairpin ribozymes.

Authors:  Yan-Li Li; Marie-Christine Maurel; Christine Ebel; Jacques Vergne; Vitaliy Pipich; Giuseppe Zaccai
Journal:  Eur Biophys J       Date:  2007-09-25       Impact factor: 1.733

5.  A comparison among the models proposed to explain the origin of the tRNA molecule: A synthesis.

Authors:  Massimo Di Giulio
Journal:  J Mol Evol       Date:  2009-06-02       Impact factor: 2.395

6.  Was there a universal tRNA before specialized tRNAs came into existence?

Authors:  J C Lacey; M P Staves
Journal:  Orig Life Evol Biosph       Date:  1990       Impact factor: 1.950

7.  The evolutionary history of the structure of 5S ribosomal RNA.

Authors:  Feng-Jie Sun; Gustavo Caetano-Anollés
Journal:  J Mol Evol       Date:  2009-07-29       Impact factor: 2.395

Review 8.  Powering through ribosome assembly.

Authors:  Bethany S Strunk; Katrin Karbstein
Journal:  RNA       Date:  2009-10-22       Impact factor: 4.942

Review 9.  Structure, function and evolution of seryl-tRNA synthetases: implications for the evolution of aminoacyl-tRNA synthetases and the genetic code.

Authors:  M Härtlein; S Cusack
Journal:  J Mol Evol       Date:  1995-05       Impact factor: 2.395

10.  The presence of codon-anticodon pairs in the acceptor stem of tRNAs.

Authors:  S Rodin; A Rodin; S Ohno
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-14       Impact factor: 11.205
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