Literature DB >> 7226972

Cefamandole bone diffusion in patients undergoing total hip replacement.

A J Roncoroni, C Manuel, C Nedjar, J Bauchet, D Mariani.   

Abstract

Cefamandole penetration was studied in 32 normal bone specimens. No antibiotic bone binding was found. Blood contamination of bone samples was measured by the haemoglobin method. Mean corrected levels attained (5.8 micrograms/g) exceed MIC values of sensitive Staphylococcus aureus, Haemophilus influenzae and Enterobacteriaceae. Similar diffusion was observed in cortical and trabecular bone. The results obtained invite further studies on preoperative prophylaxis and treatment of osteomyelitis.

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Year:  1981        PMID： 7226972     DOI： 10.1159/000237973

Source DB:  PubMed          Journal:  Chemotherapy        ISSN： 0009-3157            Impact factor:   2.544


  9 in total

1.  Penetration of vancomycin in uninfected sternal bone.

Authors:  L Massias; C Dubois; P de Lentdecker; O Brodaty; M Fischler; R Farinotti
Journal:  Antimicrob Agents Chemother       Date:  1992-11       Impact factor: 5.191

2.  Vancomycin concentrations in infected and noninfected human bone.

Authors:  A L Graziani; L A Lawson; G A Gibson; M A Steinberg; R R MacGregor
Journal:  Antimicrob Agents Chemother       Date:  1988-09       Impact factor: 5.191

Review 3.  Methicillin-resistant staphylococci in clean surgery. Is there a role for prophylaxis?

Authors:  E Mini; S Nobili; P Periti
Journal:  Drugs       Date:  1997       Impact factor: 9.546

4.  Assessment of two penicillins plus beta-lactamase inhibitors versus cefotaxime in treatment of murine Klebsiella pneumoniae infections.

Authors:  J L Fournier; F Ramisse; A C Jacolot; M Szatanik; O J Petitjean; J M Alonso; M R Scavizzi
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

5.  Cefixime penetration in human renal parenchyma.

Authors:  A Leroy; B Oser; P Grise; G Humbert
Journal:  Antimicrob Agents Chemother       Date:  1995-06       Impact factor: 5.191

6.  Measurement of the concentration of three antituberculosis drugs in the focus of spinal tuberculosis.

Authors:  Zhaohui Ge; Zili Wang; Mingji Wei
Journal:  Eur Spine J       Date:  2008-09-16       Impact factor: 3.134

7.  Pharmacokinetics and tissue penetration of a single dose of ceftriaxone (1,000 milligrams intravenously) for antibiotic prophylaxis in thoracic surgery.

Authors:  C Martin; J Ragni; F Lokiec; J C Guillen; A Auge; M Pecking; F Gouin
Journal:  Antimicrob Agents Chemother       Date:  1992-12       Impact factor: 5.191

8.  Aztreonam penetration into synovial fluid and bone.

Authors:  C M MacLeod; E A Bartley; J O Galante; L T Friedhoff; R Dhruv
Journal:  Antimicrob Agents Chemother       Date:  1986-04       Impact factor: 5.191

9.  Glycopeptide bone penetration in patients with septic pseudoarthrosis of the tibia.

Authors:  Silvia Garazzino; Alessandro Aprato; Lorena Baietto; Antonio D'Avolio; Agostino Maiello; Francesco Giuseppe De Rosa; Domenico Aloj; Marco Siccardi; Antonio Biasibetti; Alessandro Massè; Giovanni Di Perri
Journal:  Clin Pharmacokinet       Date:  2008       Impact factor: 6.447
  9 in total

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