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Literature DB >> 3707115

Aztreonam penetration into synovial fluid and bone.

C M MacLeod, E A Bartley, J O Galante, L T Friedhoff, R Dhruv.

Abstract

Eighteen patients with uncomplicated degenerative joint disease requiring joint replacement (hip or knee) were given a single 2-g intravenous dose of aztreonam over a 5-min period preoperatively. The mean concentration in synovial fluid of 83.0 +/- 9.2 micrograms/ml averaged 0.99 times the concomitant levels in serum. The mean concentration in cancellous bone of 16.0 +/- 4.3 micrograms/g averaged 0.20 times the concomitant levels in serum.

Entities: Chemical Disease Species

Mesh：

Substances：
Aztreonam

Year: 1986 PMID： 3707115 PMCID： PMC180473 DOI： 10.1128/AAC.29.4.710

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

30 in total

1. Gram-negative bacillary septic arthritis: clinical, radiographic, therapeutic, and prognostic features.

Authors: A S Bayer; A W Chow; J S Louie; K M Nies; L B Guze
Journal: Semin Arthritis Rheum Date: 1977-11 Impact factor: 5.532

2. The penetration of penicillin and other antimicrobials into joint fluid. Three case reports with a reappraisal of the literature.

Authors: D J Drutz; W Schaffner; J W Hillman; M G Koenig
Journal: J Bone Joint Surg Am Date: 1967-10 Impact factor: 5.284

3. Bacterial arthritis in the adult.

Authors: P J Kelly
Journal: Orthop Clin North Am Date: 1975-10 Impact factor: 2.472

4. Penetration of methicillin, oxacillin, and cephalothin into bone and synovial tissues.

Authors: R H Fitzgerald; P J Kelly; R J Snyder; J A Washington
Journal: Antimicrob Agents Chemother Date: 1978-11 Impact factor: 5.191

5. Gentamicin and tobramycin penetration into synovial fluid.

Authors: T H Dee; F Kozin
Journal: Antimicrob Agents Chemother Date: 1977-10 Impact factor: 5.191

6. Penetration of antitubercular drugs in clinical osteoarticular tubercular lesions.

Authors: S M Tuli; K Kumar; P C Sen
Journal: Acta Orthop Scand Date: 1977

7. Antibiotic bone penetration. Concentrations of methicillin and clindamycin phosphate in human bone taken during total hip replacement.

Authors: D J Schurman; B L Johnson; G Finerman; H C Amstutz
Journal: Clin Orthop Relat Res Date: 1975-09 Impact factor: 4.176

Aztreonam penetration into synovial fluid and bone.

1. Gram-negative bacillary septic arthritis: clinical, radiographic, therapeutic, and prognostic features.

2. The penetration of penicillin and other antimicrobials into joint fluid. Three case reports with a reappraisal of the literature.

3. Bacterial arthritis in the adult.

4. Penetration of methicillin, oxacillin, and cephalothin into bone and synovial tissues.

5. Gentamicin and tobramycin penetration into synovial fluid.

6. Penetration of antitubercular drugs in clinical osteoarticular tubercular lesions.

7. Antibiotic bone penetration. Concentrations of methicillin and clindamycin phosphate in human bone taken during total hip replacement.

8. Review of septic arthritis throughout the antibiotic era.

9. Antibiotics in bone tissues. Methodological and practical aspects.

10. Aztreonam: worldwide overview of the treatment of patients with gram-negative infections.

Review 1. Pharmacokinetic optimisation of the treatment of septic arthritis.

2. Gentamicin in bone cement: A potentially more effective prophylactic measure of infectionin joint arthroplasty.