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Literature DB >> 71736

Key antigenic determinants in regulation of the immune response.

Abstract

The immune response to beta-galactosidase (beta-D-galactoside galactohydrolase; EC 3.2.1.23)is characterized by a wave of early help followed by a wave of suppression to a subsequent in vitro challenge with galactosidase-fluorescein. A cyanogen bromide peptide of beta-galactosidase, CB2, mimics the suppression seen with the enzyme. It is time dependent, carrier specific, and anti-theta sensitive; however, this suppression is not preceded by a wave of help. It is possible that CB2 cannot stimulate helpers, and is only able to activate suppressor cells. These data indicate that one small region of an antigen, capable of activating suppressors, can nullify the positive effect induced in helper T cells reactive with other epitopes on beta-galactosidase. Key determinants on macromolecules may in this way be influential in regulating the immune response to the entire antigen molecule.

Entities: Chemical Gene

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Year: 1977 PMID： 71736 PMCID： PMC431811 DOI： 10.1073/pnas.74.9.3984

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

20 in total

Review 1. Properties of primed suppressor T cells and their products.

Authors: T Tada; M Taniguchi; T Takemori
Journal: Transplant Rev Date: 1975

Review 2. Differential function of major histocompatibility complex antigens in T-lymphocyte activation.

Authors: F H Bach; M L Bach; P M Sondel
Journal: Nature Date: 1976-01-29 Impact factor: 49.962

3. The suppressive effect of carrier priming on the response to a hapten-carrier conjugate.

Authors: C J Elson; R B Taylor
Journal: Eur J Immunol Date: 1974-10 Impact factor: 5.532

4. High-level production of -galactosidase by Escherichia coli merodiploids.

Authors: A V Fowler
Journal: J Bacteriol Date: 1972-11 Impact factor: 3.490

5. Immunoglobulin determinants on the lymphocytes of normal rabbits. 3. As4 and As6 determinants on individual lymphocytes and the concept of allelic exclusion.

Authors: B Wolf; C A Janeway; R R Coombs; D Catty; P G Gell; A S Kelus
Journal: Immunology Date: 1971-06 Impact factor: 7.397

6. Genetic control of immune responses in vitro. VI. Experimental conditions for the development of helper T-cell activity specific for the terpolymer L-glutamic aicd60-L-alanine30-L-tyrosine10 (GAT) in nonresponder mice.

Authors: J A Kapp; C W Pierce; B Benacerraf
Journal: J Exp Med Date: 1975-07-01 Impact factor: 14.307

7. Antigen-induced inhibition of experimental allergic encephalomyelitis. III. Localization of an inhibitory site distinct from the major encephalitogenic determinant of myelin basic protein.

Authors: R H Swanborg
Journal: J Immunol Date: 1975-01 Impact factor: 5.422

8. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

Authors: H Cantor; E A Boyse
Journal: J Exp Med Date: 1975-06-01 Impact factor: 14.307

9. Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.

Authors: H Cantor; E A Boyse
Journal: J Exp Med Date: 1975-06-01 Impact factor: 14.307

10. H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus.

Authors: P C Doherty; R M Zinkernagel
Journal: J Exp Med Date: 1975-02-01 Impact factor: 14.307

13 in total

1. Immunological properties of peptic fragments of bovine serum albumin.

Authors: S Dosa; A J Pesce; D J Ford; A Muckerheide; J G Michael
Journal: Immunology Date: 1979-11 Impact factor: 7.397

Review 2. Epitope-specific and idiotype-specific cellular interactions in a model protein antigen system.

Authors: E E Sercarz; D W Metzger
Journal: Springer Semin Immunopathol Date: 1980-08

Review 3. Function of macrophages as antigen presenting cells.

Authors: J Schroer; A S Rosenthal
Journal: Springer Semin Immunopathol Date: 1980-08

Review 4. Coexistence of immunogenic and suppressogenic epitopes in tumor cells and various types of macromolecules.

Authors: D Naor
Journal: Cancer Immunol Immunother Date: 1983 Impact factor: 6.968

5. Strain differences in the immune response of mice to horseradish peroxidase.

Authors: D Kovatchev; T Ternynck; J L Guenet; S Avrameas
Journal: Immunology Date: 1983-02 Impact factor: 7.397

6. Requirement for the location of both appropriate and irrelevant H-2 antigens on the same stimulator cell for unspecific DNA-synthesis inhibition by the H-2-antigen-primed, specific suppressor T cells.

Authors: B D Brondz; A V Karaulov; A V Chervonsky; Z K Blandova
Journal: Immunogenetics Date: 1982 Impact factor: 2.846

7. Modification of the anti-tumour immune response by suppressor gene products of lymphoid cells.

Authors: L De Giorgi; A Matossian-Rogers; H Festenstein
Journal: Immunology Date: 1979-04 Impact factor: 7.397

8. Delayed hypersensitivity responses to human IgG and methylated bovine serum albumin are regulated by different mechanisms.

Authors: C Clark; A P Dalmasso
Journal: Immunology Date: 1982-09 Impact factor: 7.397

9. Specificity and in vitro transfer of the immunosuppressive effect of detergent-disrupted influenza virus vaccine.

Authors: T L Smith; R Jennings
Journal: Clin Exp Immunol Date: 1990-01 Impact factor: 4.330

10. Repertoires of T cells directed against a large protein antigen, beta-galactosidase. II. Only certain T helper or T suppressor cells are relevant in particular regulatory interactions.

Authors: U Krzych; A V Fowler; E E Sercarz
Journal: J Exp Med Date: 1985-07-01 Impact factor: 14.307