J E Castelao1, M Gago-Dominguez, J M Yuan, R K Ross, M C Yu. 1. Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089-9175, USA. castelao@hsc.usc.edu
Abstract
BACKGROUND: Two epidemiologic studies have reported an inverse association between use of phenobarbital (PB) and bladder cancer development. It was proposed that PB use protects against bladder cancer by inducing enzymes that participate in the detoxification of human bladder carcinogens, such as the aminobiphenyls and naphthylamines, which are found in cigarette smoke. METHODS: A population-based case-control study was conducted in Los Angeles, California, involving 815 incident bladder cancer cases and an equal number of controls who were matched to the index cases by neighborhood, sex, date of birth (within 5 years), and race. Detailed information on lifetime use of PB was collected through in-person interviews. RESULTS: Ever use (20 or more times over lifetime) of PB was not associated with risk of bladder cancer (OR: 0.86; 95% CI: 0.54, 1.39). Regular use of PB also was not associated with risk of bladder cancer in either men or women, in either smokers or non-smokers, although the number of regular users in cases and controls were relatively small (21 cases vs. 15 controls, OR: 1.20; 95% CI: 0.59, 2.45). In fact, compared with non-users, subjects in the highest category of lifetime PB consumption were at a non-significant 2.46-fold increased risk of bladder cancer (95% CI: 0.90, 6.78). CONCLUSIONS: The present study did not observe a protective role of PB use in bladder cancer development in the general population.
BACKGROUND: Two epidemiologic studies have reported an inverse association between use of phenobarbital (PB) and bladder cancer development. It was proposed that PB use protects against bladder cancer by inducing enzymes that participate in the detoxification of humanbladder carcinogens, such as the aminobiphenyls and naphthylamines, which are found in cigarette smoke. METHODS: A population-based case-control study was conducted in Los Angeles, California, involving 815 incident bladder cancer cases and an equal number of controls who were matched to the index cases by neighborhood, sex, date of birth (within 5 years), and race. Detailed information on lifetime use of PB was collected through in-person interviews. RESULTS: Ever use (20 or more times over lifetime) of PB was not associated with risk of bladder cancer (OR: 0.86; 95% CI: 0.54, 1.39). Regular use of PB also was not associated with risk of bladder cancer in either men or women, in either smokers or non-smokers, although the number of regular users in cases and controls were relatively small (21 cases vs. 15 controls, OR: 1.20; 95% CI: 0.59, 2.45). In fact, compared with non-users, subjects in the highest category of lifetime PB consumption were at a non-significant 2.46-fold increased risk of bladder cancer (95% CI: 0.90, 6.78). CONCLUSIONS: The present study did not observe a protective role of PB use in bladder cancer development in the general population.
Authors: J Whysner; F Montandon; R M McClain; J Downing; L K Verna; R E Steward; G M Williams Journal: Toxicol Appl Pharmacol Date: 1998-01 Impact factor: 4.219
Authors: J H Olsen; H Wallin; J D Boice; K Rask; G Schulgen; J F Fraumeni Journal: Cancer Epidemiol Biomarkers Prev Date: 1993 Sep-Oct Impact factor: 4.254
Authors: M C Yu; P L Skipper; K Taghizadeh; S R Tannenbaum; K K Chan; B E Henderson; R K Ross Journal: J Natl Cancer Inst Date: 1994-05-04 Impact factor: 13.506
Authors: Cristiane Murta-Nascimento; Bernd J Schmitz-Dräger; Maurice P Zeegers; Gunnar Steineck; Manolis Kogevinas; Francisco X Real; Núria Malats Journal: World J Urol Date: 2007-06 Impact factor: 3.661