Literature DB >> 7149998

Inhibition of interferon secretion in human fibroblast by vinblastine.

F H Sarkar, S L Gupta.   

Abstract

Vinblastine treatment of superinduced human fibroblast (FS-4) cultures strongly inhibited interferon (IFN) secretion and resulted in intracellular accumulation of IFN activity. The cell-associated IFN migrated slower than secreted IFN in sodium dodecyl sulfate-polyacrylamide gel electrophoresis, indicating a larger size. The results suggest the presence of a possible precursor form of mature HuIFN-beta with biological activity.

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Year:  1982        PMID： 7149998     DOI： 10.1007/bf01318088

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  15 in total

1.  Characterization of the heterogeneous molecules of human interferons: differences in the cross-species antiviral activities of various molecular populations in human leukocyte interferons.

Authors:  L S Lin; M Wiranowska-Stewart; T Chudzio; W E Stewart
Journal:  J Gen Virol       Date:  1978-04       Impact factor: 3.891

2.  Molecular cloning of human interferon cDNA.

Authors:  T Taniguchi; Y Fujii-Kuriyama; M Muramatsu
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

3.  Heterogeneity of poly(I) x poly(C)-induced human fibroblast interferon mRNA species.

Authors:  P B Sehgal; A D Sagar
Journal:  Nature       Date:  1980-11-06       Impact factor: 49.962

4.  Human fibroblast interferon. An improved purification.

Authors:  E Knight; D Fahey
Journal:  J Biol Chem       Date:  1981-04-25       Impact factor: 5.157

5.  Translocation of proteins across membranes: the signal hypothesis and beyond.

Authors:  G Blobel; P Walter; C N Chang; B M Goldman; A H Erickson; V R Lingappa
Journal:  Symp Soc Exp Biol       Date:  1979

6.  The mechanism of protein secretion across membranes.

Authors:  B D Davis; P C Tai
Journal:  Nature       Date:  1980-01-31       Impact factor: 49.962

7.  Repeated 'superinduction' of interferon in human diploid fibroblast cultures.

Authors:  M Wiranowska-Stewart; T Chudzio; W E Stewart
Journal:  J Gen Virol       Date:  1977-10       Impact factor: 3.891

8.  The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase.

Authors:  M Houghton; M A Easton; A G Stewart; J C Smith; S M Doel; G H Catlin; H M Lewis; T P Patel; J S Emtage; N H Carey; A G Porter
Journal:  Nucleic Acids Res       Date:  1980-07-11       Impact factor: 16.971

9.  Human fibroblastoid interferon: immunosorbent column chromatography and N-terminal amino acid sequence.

Authors:  H Okamura; W Berthold; L Hood; M Hunkapiller; M Inoue; H Smith-Johannsen; Y H Tan
Journal:  Biochemistry       Date:  1980-08-05       Impact factor: 3.162

10.  Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

Authors:  G Blobel; B Dobberstein
Journal:  J Cell Biol       Date:  1975-12       Impact factor: 10.539
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