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Literature DB >> 7352023

The mechanism of protein secretion across membranes.

Abstract

Many secreted proteins are synthesised as a large precursor with an additional hydrophobic N-terminal signal sequence that is cleaved by a membrane-bound enzyme. The proteins are secreted as nascent chains. The work leading to the current models of protein secretion is reviewed and the value of bacterial systems in the study of protein transfer across membranes is stressed.

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Year: 1980 PMID： 7352023 DOI： 10.1038/283433a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

83 in total

1. Temperature-dependent insertion of prolipoprotein into Escherichia coli membrane vesicles and requirements for ATP, soluble factors, and functional SecY protein for the overall translocation process.

Authors: G Tian; H C Wu; P H Ray; P C Tai
Journal: J Bacteriol Date: 1989-04 Impact factor: 3.490

2. Biochemical evidence for the secY24 defect in Escherichia coli protein translocation and its suppression by soluble cytoplasmic factors.

Authors: J P Fandl; P C Tai
Journal: Proc Natl Acad Sci U S A Date: 1987-11 Impact factor: 11.205

3. Monoclonal antibody to the amino-terminal L sequence of murine leukemia virus glycosylated gag polyproteins demonstrates their unusual orientation in the cell membrane.

Authors: E A Pillemer; D A Kooistra; O N Witte; I L Weissman
Journal: J Virol Date: 1986-02 Impact factor: 5.103

4. In vitro cell-free synthesis of bullous pemphigoid polypeptide.

Authors: S Miyakawa; S Tajima; T Nishikawa
Journal: Arch Dermatol Res Date: 1989 Impact factor: 3.017

5. Purification, characterization, and primary structure of Escherichia coli protease VII with specificity for paired basic residues: identity of protease VII and OmpT.

Authors: K Sugimura; T Nishihara
Journal: J Bacteriol Date: 1988-12 Impact factor: 3.490

10. Length and structural effect of signal peptides derived from Bacillus subtilis alpha-amylase on secretion of Escherichia coli beta-lactamase in B. subtilis cells.

Authors: K Ohmura; K Nakamura; H Yamazaki; T Shiroza; K Yamane; Y Jigami; H Tanaka; K Yoda; M Yamasaki; G Tamura
Journal: Nucleic Acids Res Date: 1984-07-11 Impact factor: 16.971

The mechanism of protein secretion across membranes.

1. Temperature-dependent insertion of prolipoprotein into Escherichia coli membrane vesicles and requirements for ATP, soluble factors, and functional SecY protein for the overall translocation process.

2. Biochemical evidence for the secY24 defect in Escherichia coli protein translocation and its suppression by soluble cytoplasmic factors.

3. Monoclonal antibody to the amino-terminal L sequence of murine leukemia virus glycosylated gag polyproteins demonstrates their unusual orientation in the cell membrane.

4. In vitro cell-free synthesis of bullous pemphigoid polypeptide.

5. Purification, characterization, and primary structure of Escherichia coli protease VII with specificity for paired basic residues: identity of protease VII and OmpT.

6. Molecular cloning of Vibrio cholerae enterotoxin genes in Escherichia coli K-12.

7. Structure and mode of action of microcin 7, an antibacterial peptide produced by Escherichia coli.

8. ATP is essential for protein translocation into Escherichia coli membrane vesicles.

9. Regulation of staphylococcal toxic shock syndrome toxin-1 and total exoprotein production by magnesium ion.

10. Length and structural effect of signal peptides derived from Bacillus subtilis alpha-amylase on secretion of Escherichia coli beta-lactamase in B. subtilis cells.