Literature DB >> 7137979

Pharmacokinetics of amoxicillin and clavulanic acid administered alone and in combination.

D Adam, I de Visser, P Koeppe.   

Abstract

The pharmacokinetics of amoxicillin and clavulanic acid, administered alone and in combination, were studied in six male and six female normal human volunteers. Each ingested 500 mg of amoxicillin or 125 mg of clavulanic acid or the above agents in combination in randomized sequences. The results indicate that most of the parameters tested for either substance are essentially independent of the presence of the other one.

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Year:  1982        PMID： 7137979      PMCID： PMC183747          DOI： 10.1128/AAC.22.3.353

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus.

Authors:  C Reading; M Cole
Journal:  Antimicrob Agents Chemother       Date:  1977-05       Impact factor: 5.191

Review 2.  Plasmid-mediated beta-lactamases of Gram-negative bacteria: properties and distribution.

Authors:  M Matthew
Journal:  J Antimicrob Chemother       Date:  1979-07       Impact factor: 5.790

3.  Simplified, accurate method for antibiotic assay of clinical specimens.

Authors:  J V Bennett; J L Brodie; E J Benner; W M Kirby
Journal:  Appl Microbiol       Date:  1966-03

4.  A program for non-linear regression analysis to be used on desk-top computers.

Authors:  P Koeppe; C Hamann
Journal:  Comput Programs Biomed       Date:  1980-12

5.  Amoxycillin and clavulanic acid in intra-abdominal and pelvic sepsis.

Authors:  P Ball; T Watson; S Mehtar
Journal:  J Antimicrob Chemother       Date:  1981-04       Impact factor: 5.790

6.  Comparative activity of BRL 25.000 with amoxycillin against resistant clinical isolates.

Authors:  H W Van Landuyt; M Pyckavet; A M Lambert
Journal:  J Antimicrob Chemother       Date:  1981-01       Impact factor: 5.790

7.  The inhibition of staphylococcal beta-lactamase by clavulanic acid.

Authors:  C Reading; P Hepburn
Journal:  Biochem J       Date:  1979-04-01       Impact factor: 3.857

8.  In vitro-activity of clavulanic acid and amoxicillin combined against amoxicillin-resistant bacteria.

Authors:  G Peters; G Pulverer; M Neugebauer
Journal:  Infection       Date:  1980       Impact factor: 3.553

9.  Clavulanic acid, a novel inhibitor of beta-lactamases.

Authors:  H C Neu; K P Fu
Journal:  Antimicrob Agents Chemother       Date:  1978-11       Impact factor: 5.191

10.  Combined antibacterial activity of amoxicillin with clavulanic acid against ampicillin-resistant strains.

Authors:  M Matsuura; H Nakazawa; T Hashimoto; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1980-06       Impact factor: 5.191
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  29 in total

Review 1.  New formulations of amoxicillin/clavulanic acid: a pharmacokinetic and pharmacodynamic review.

Authors:  Amparo Sánchez Navarro
Journal:  Clin Pharmacokinet       Date:  2005       Impact factor: 6.447

2.  Pharmacokinetics of amoxicillin in maternal, umbilical cord, and neonatal sera.

Authors:  Anouk E Muller; Paul M Oostvogel; Joost DeJongh; Johan W Mouton; Eric A P Steegers; P Joep Dörr; Meindert Danhof; Rob A Voskuyl
Journal:  Antimicrob Agents Chemother       Date:  2009-01-21       Impact factor: 5.191

3.  Activity of amoxicillin-clavulanate against penicillin-resistant Streptococcus pneumoniae in an experimental respiratory infection model in rats.

Authors:  G M Smith; B Slocombe; K H Abbott; L W Mizen
Journal:  Antimicrob Agents Chemother       Date:  1998-04       Impact factor: 5.191

4.  Evaluation of piperacillin-tazobactam in experimental meningitis caused by a beta-lactamase-producing strain of K1-positive Escherichia coli.

Authors:  W Kern; S L Kennedy; M Sachdeva; E R Sande; D Gunderson; M G Täuber
Journal:  Antimicrob Agents Chemother       Date:  1990-05       Impact factor: 5.191

5.  In vitro assessment of the effect of clavulanic acid at concentrations achieved in human serum on the bactericidal activity of amoxicillin at physiological concentrations against Staphylococcus aureus: implications for dosage regimens.

Authors:  L Aguilar; M Martín; I P Balcabao; M L Gómez-Lus; R Dal-Ré; J Prieto
Journal:  Antimicrob Agents Chemother       Date:  1997-06       Impact factor: 5.191

6.  Effect of clavulanic acid and/or polymorphonuclear neutrophils on amoxicillin bactericidal activity against Streptococcus pneumoniae.

Authors:  M Martín; M L Gómez-Lus; L Aguilar; P Martínez; M J Giménez; J Prieto
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1997-07       Impact factor: 3.267

Review 7.  Beta-lactamase inhibitors from laboratory to clinic.

Authors:  K Bush
Journal:  Clin Microbiol Rev       Date:  1988-01       Impact factor: 26.132

8.  Development and validation of limited-sampling strategies for predicting amoxicillin pharmacokinetic and pharmacodynamic parameters.

Authors:  G Suarez-Kurtz; F M Ribeiro; F L Vicente; C J Struchiner
Journal:  Antimicrob Agents Chemother       Date:  2001-11       Impact factor: 5.191

9.  Concentrations of ticarcillin and clavulanic acid in human bone after prophylactic administration of 5.2 g of timentin.

Authors:  D Adam; H D Heilmann; K Weismeier
Journal:  Antimicrob Agents Chemother       Date:  1987-06       Impact factor: 5.191

Review 10.  Penicillins. A current review of their clinical pharmacology and therapeutic use.

Authors:  Dilip Nathwani; Martin J Wood
Journal:  Drugs       Date:  1993-06       Impact factor: 9.546
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