Literature DB >> 6967713

Combined antibacterial activity of amoxicillin with clavulanic acid against ampicillin-resistant strains.

M Matsuura, H Nakazawa, T Hashimoto, S Mitsuhashi.   

Abstract

Strains of bacteria resistant to beta-lactam antibiotics have been increasing in number and are becoming troublesome in clinical medicine. The in vitro antibacterial activity of amoxicillin combined with clavulanic acid was determined on selected ampicillin-resistant clinical isolates. Synergistic effects were produced by amoxicillin with clavulanic acid against ampicillin-resistant strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, and Bacteroides fragilis. Inhibition of the beta-lactamases produced by the ampicillin-resistant strains was confirmed, especially against the penicillinases mediated by the R factor and the cephalosporinases produced by P.vulgaris and B. fragilis. The inhibitory effect of clavulanic acid against beta-lactamases was irreversible because of the high affinity of clavulanic acid to the enzymes.

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Year:  1980        PMID： 6967713      PMCID： PMC283901          DOI： 10.1128/AAC.17.6.908

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Biochemical properties of a penicillin beta-lactamase mediated by R factor from Bordetella bronchiseptica.

Authors:  S Yaginuma; N Terakado; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1975-09       Impact factor: 5.191

2.  Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus.

Authors:  C Reading; M Cole
Journal:  Antimicrob Agents Chemother       Date:  1977-05       Impact factor: 5.191

3.  Naturally-occurring beta-lactamase inhibitors with antibacterial activity.

Authors:  A G Brown; D Butterworth; M Cole; G Hanscomb; J D Hood; C Reading; G N Rolinson
Journal:  J Antibiot (Tokyo)       Date:  1976-06       Impact factor: 2.649

4.  CP-45,899, a beta-lactamase inhibitor that extends the antibacterial spectrum of beta-lactams: initial bacteriological characterization.

Authors:  A R English; J A Retsema; A E Girard; J E Lynch; W E Barth
Journal:  Antimicrob Agents Chemother       Date:  1978-09       Impact factor: 5.191

5.  Combined activitiy of clavulanic acid and ticarcillin against ticarcillin-resistant, gram-negative bacilli.

Authors:  J W Paisley; J A Washington
Journal:  Antimicrob Agents Chemother       Date:  1978-08       Impact factor: 5.191

6.  The purification and properties of penicillin beta-lactamases mediated by transmissible R factors in Escherichia coli.

Authors:  S Yamagishi; K O'Hara; T Sawai; S Mitsuhashi
Journal:  J Biochem       Date:  1969-07       Impact factor: 3.387

7.  Cefuroxime, a new cephalosporin antibiotic: activity in vitro.

Authors:  C H O'Callaghan; R B Sykes; A Griffiths; J E Thornton
Journal:  Antimicrob Agents Chemother       Date:  1976-03       Impact factor: 5.191

8.  Demonstration of R factors from Pseudomonas aeruginosa.

Authors:  S Iyobe; K Hasuda; A Fuse; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1974-06       Impact factor: 5.191

9.  Antimicrobial evaluation of cefoxitin: a new semisynthetic cephamycin. Comparative studies with cefazolin and cefalotin.

Authors:  T Une; S Mitsuhashi
Journal:  Arzneimittelforschung       Date:  1977

10.  Sodium clavulanate potentiation of cephalosporin activity against clinical isolates of cephalothin-resistant Klebsiella pneumoniae.

Authors:  R T Jackson; L F Harris; R H Alford
Journal:  Antimicrob Agents Chemother       Date:  1978-07       Impact factor: 5.191
  10 in total
  17 in total

Review 1.  Mechanisms of drug combinations: interaction and network perspectives.

Authors:  Jia Jia; Feng Zhu; Xiaohua Ma; Zhiwei Cao; Zhiwei W Cao; Yixue Li; Yixue X Li; Yu Zong Chen
Journal:  Nat Rev Drug Discov       Date:  2009-02       Impact factor: 84.694

2.  Comparative efficacies of amoxicillin-clavulanic acid and ampicillin-sulbactam against experimental Bacteroides fragilis-Escherichia coli mixed infections.

Authors:  J Gisby; A S Beale
Journal:  Antimicrob Agents Chemother       Date:  1988-12       Impact factor: 5.191

Review 3.  Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review.

Authors:  Peter Csermely; Tamás Korcsmáros; Huba J M Kiss; Gábor London; Ruth Nussinov
Journal:  Pharmacol Ther       Date:  2013-02-04       Impact factor: 12.310

4.  Efficacy of BRL 25000 against Serratia marcescens, Enterobacter cloacae, and Citrobacter freundii in urinary tract infections.

Authors:  H Nakazawa; T Hashimoto; T Nishiura; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1983-09       Impact factor: 5.191

5.  Synergistic antibacterial activity of clavulanic acid and amoxicillin against beta-lactamase-producing strains of Haemophilus ducreyi.

Authors:  Y C Girouard; I W Maclean; A R Ronald; W L Albritton
Journal:  Antimicrob Agents Chemother       Date:  1981-07       Impact factor: 5.191

6.  Activities of amoxicillin and clavulanic acid combinations against urinary tract infections.

Authors:  F Crokaert; M P van der Linden; E Yourassowsky
Journal:  Antimicrob Agents Chemother       Date:  1982-08       Impact factor: 5.191

Review 7.  Amoxycillin/clavulanic acid: a review of its antibacterial activity, pharmacokinetics and therapeutic use.

Authors:  R N Brogden; A Carmine; R C Heel; P A Morley; T M Speight; G S Avery
Journal:  Drugs       Date:  1981-11       Impact factor: 9.546

Review 8.  Antibiotic resistance in pathogenic and producing bacteria, with special reference to beta-lactam antibiotics.

Authors:  H Ogawara
Journal:  Microbiol Rev       Date:  1981-12

9.  In vitro and in vivo synergism between amoxicillin and clavulanic acid against ampicillin-resistant Haemophilus influenzae type b.

Authors:  R Yogev; C Melick; W J Kabat
Journal:  Antimicrob Agents Chemother       Date:  1981-06       Impact factor: 5.191

10.  Potent cephalosporinase inhibitors: 7 beta-[2-(1, 3-dithiolan-2-ylidene) acetamido] cephalosporins and related compounds.

Authors:  S Ohya; T Miyadera; M Yamazaki
Journal:  Antimicrob Agents Chemother       Date:  1982-04       Impact factor: 5.191
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