Literature DB >> 7130161

Isolation and properties of Ca2+-transporting glycoprotein and peptide from beef heart mitochondria.

G D Mironova, T V Sirota, L A Pronevich, N V Trofimenko, G P Mironov, P A Grigorjev, M N Kondrashova.   

Abstract

The 40,000-dalton glycoprotein and 2000-dalton peptide inducing selective Ca2+-transport through bilayer lipid membranes were isolated from beef heart homogenate and mitochondria. Micromolar concentrations of these substances were found to increase the conductivity of membranes by 3-4 orders. Trans-membrane Ca2+ gradient induces an electric potential difference whose magnitude is close to the theoretical for ideal Ca2+ selectivity. The inhibitor of mitochondrial Ca2+ transport, ruthenium red, abolishes both the glycoprotein- and peptide-induced Ca2+ transport in bilayer lipid membranes. Thiol groups essential for Ca2+ transport activity were revealed in the glycoprotein and peptide. Addition of these substances to rat liver mitochondria induces Ca2+-dependent inhibition of the state 3 respiration that can be released by uncouplers (oligomycin-like effect).

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Year:  1982        PMID： 7130161     DOI： 10.1007/bf00751016

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   2.945


  24 in total

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5.  Isolation of a soluble Ca 2+ binding glycoprotein from ox liver mitochondria.

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Authors:  A Gomez-Puyou; M T De Gomez-Puyou; G Becker; A L Lehninger
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10.  [Sensitive fluorometric method of determining SH- and S-S-groups when jointly present].

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  14 in total

1.  Mitochondrial glycosidic residues contribute to the interaction between ruthenium amine complexes and the calcium uniporter.

Authors:  Francisco Correa; Cecilia Zazueta
Journal:  Mol Cell Biochem       Date:  2005-04       Impact factor: 3.396

Review 2.  Mitochondrial ion channels.

Authors:  Brian O'Rourke
Journal:  Annu Rev Physiol       Date:  2007       Impact factor: 19.318

Review 3.  Electrophysiology of the inner mitochondrial membrane.

Authors:  M Zoratti; I Szabó
Journal:  J Bioenerg Biomembr       Date:  1994-10       Impact factor: 2.945

4.  Identification of a 20-kDa protein with calcium uptake transport activity. Reconstitution in a membrane model.

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Journal:  J Bioenerg Biomembr       Date:  1994-10       Impact factor: 2.945

Review 5.  Mitochondrial cation transport: a progress report.

Authors:  K D Garlid
Journal:  J Bioenerg Biomembr       Date:  1994-10       Impact factor: 2.945

6.  Purification of the channel component of the mitochondrial calcium uniporter and its reconstitution into planar lipid bilayers.

Authors:  G D Mironova; M Baumann; O Kolomytkin; Z Krasichkova; A Berdimuratov; T Sirota; I Virtanen; N E Saris
Journal:  J Bioenerg Biomembr       Date:  1994-04       Impact factor: 2.945

Review 7.  The molecular identity of the mitochondrial Ca2+ sequestration system.

Authors:  Anatoly A Starkov
Journal:  FEBS J       Date:  2010-07-26       Impact factor: 5.542

8.  Inhibition of the mitochondrial calcium uniporter by antibodies against a 40-kDa glycoproteinT.

Authors:  N E Saris; T V Sirota; I Virtanen; K Niva; T Penttilä; L P Dolgachova; G D Mironova
Journal:  J Bioenerg Biomembr       Date:  1993-06       Impact factor: 2.945

Review 9.  Modulation of inner mitochondrial membrane channel activity.

Authors:  K W Kinnally; Y N Antonenko; D B Zorov
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10.  The alpha-adrenergic-mediated activation of the cardiac mitochondrial Ca2+ uniporter and its role in the control of intramitochondrial Ca2+ in vivo.

Authors:  M Crompton; P Kessar; I Al-Nasser
Journal:  Biochem J       Date:  1983-11-15       Impact factor: 3.857
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