Literature DB >> 7117352

Effects of chlorpromazine and other drugs acting on the central nervous system on human sperm motility.

C Y Hong, D M Chaput de Saintonge, P Turner.   

Abstract

The in vitro effects of chlorpromazine, diazepam, phenytoin and phenobarbitone on human sperm motility were investigated. Only chlorpromazine inhibits human sperm motility and the concentration which decreases sperm motility to 50% of control is 0.22 mM. Caffeine can shift the dose-response curve of chlorpromazine-inhibited sperm motility to right. We support the hypothesis that chlorpromazine acts on the cellular membrane but consider the inhibition of sperm motility an unlikely cause of decreased fertility in chlorpromazine treated patients.

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Year:  1982        PMID： 7117352     DOI： 10.1007/bf00542545

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  17 in total

1.  EFFECT OF TRANQUILIZERS ON LIBIDO, SPERM PRODUCTION AND IN VITRO SPERM SURVIVAL IN DOGS.

Authors:  R H FOOTE; L C GRAY
Journal:  Proc Soc Exp Biol Med       Date:  1963-11

2.  Effects of psychoactive drugs on sperm motility.

Authors:  N R Cates
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1970-03

3.  delta 9-Tetrahydrocannabinol inhibits human sperm motility.

Authors:  C Y Hong; D M Chaput de Saintonge; P Turner
Journal:  J Pharm Pharmacol       Date:  1981-11       Impact factor: 3.765

Review 4.  Neuroendocrine markers of CNS drug effects.

Authors:  E C Johnstone; I N Ferrier
Journal:  Br J Clin Pharmacol       Date:  1980-07       Impact factor: 4.335

5.  Drugs and male sexual function.

Authors: 
Journal:  Br Med J       Date:  1979-10-13

6.  Effect of psychoactive drugs on the motility of human spermatozoa.

Authors:  H Schnieden
Journal:  ICRS J Int Res Commun       Date:  1974-05

7.  The effect of some psychoactive drugs and metallic salts on the motility of rabbit spermatozoa.

Authors:  H Schnieden
Journal:  ICRS J Int Res Commun       Date:  1974-08

8.  A simple method to measure drug effects on human sperm motility.

Authors:  C Y Hong; D M Chaput de Saintonge; P Turner
Journal:  Br J Clin Pharmacol       Date:  1981-04       Impact factor: 4.335

9.  Drugs and impaired male sexual function.

Authors:  J D Horowitz; A J Goble
Journal:  Drugs       Date:  1979-09       Impact factor: 9.546

10.  Permeability of selected drugs and chemicals across the blood-testis barrier of the rat.

Authors:  K Okumura; I P Lee; R L Dixon
Journal:  J Pharmacol Exp Ther       Date:  1975-07       Impact factor: 4.030
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  4 in total

1.  Local anaesthetic effect of antiarrhythmic drugs and human sperm immobilization: mechanism and application of the interrelationship.

Authors:  C Y Hong; B N Chiang
Journal:  Br J Clin Pharmacol       Date:  1984-06       Impact factor: 4.335

2.  Leptospirosis in man, British Isles, 1983.

Authors: 
Journal:  Br Med J (Clin Res Ed)       Date:  1984-06-30

Review 3.  FDA-approved drugs that are spermatotoxic in animals and the utility of animal testing for human risk prediction.

Authors:  Elizabeth R Rayburn; Liang Gao; Jiayi Ding; Hongxia Ding; Jun Shao; Haibo Li
Journal:  J Assist Reprod Genet       Date:  2017-10-24       Impact factor: 3.412

4.  Bovine spermatozoa as an in vitro model for studies on the cytotoxicity of chemicals: effects of chlorophenols.

Authors:  H Seibert; M Kolossa; O Wassermann
Journal:  Cell Biol Toxicol       Date:  1989-11       Impact factor: 6.691
  4 in total

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