Literature DB >> 6743466

Local anaesthetic effect of antiarrhythmic drugs and human sperm immobilization: mechanism and application of the interrelationship.

C Y Hong, B N Chiang.   

Abstract

Sperm immobilizing activity of three class I antiarrhythmic drugs, quinidine, procainamide, mexiletine, one adrenoceptor blocking drug, labetalol and one calcium channel blocking drug, diltiazem was measured with a trans-membrane migration method. All these drugs immobilized human sperm. Local anaesthetic effect is the underlying mechanism for these drugs to inhibit sperm motility. Sperm immobilization could be a screening test for the local anaesthetic effect of antiarrhythmic drugs.

Entities:  

Keywords:  Contraception; Contraceptive Agents; Contraceptive Agents, Male; Contraceptive Mode Of Action; Drugs; Economic Factors; Family Planning; Fertilization; Inhibition Of Fertilization; Reproduction; Research And Development; Sperm Immobilizing Agents; Sperm Transport; Sperm Transport Inhibition; Spermicidal Contraceptive Agents; Technology; Treatment

Mesh：

Substances：

Year:  1984        PMID： 6743466      PMCID： PMC1463418          DOI： 10.1111/j.1365-2125.1984.tb02404.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  13 in total

1.  Antiarrhythmic drugs.

Authors:  W S Hillis; B Whiting
Journal:  Br Med J (Clin Res Ed)       Date:  1983-04-23

2.  delta 9-Tetrahydrocannabinol inhibits human sperm motility.

Authors:  C Y Hong; D M Chaput de Saintonge; P Turner
Journal:  J Pharm Pharmacol       Date:  1981-11       Impact factor: 3.765

3.  Mitochondrial respiration inhibitors and human sperm motility: implication in the development of spermicides.

Authors:  C Y Hong; B N Chiang; Y H Wei
Journal:  Br J Clin Pharmacol       Date:  1983-11       Impact factor: 4.335

Review 4.  Calcium antagonists: a new class of drugs.

Authors:  W G Nayler; J D Horowitz
Journal:  Pharmacol Ther       Date:  1983       Impact factor: 12.310

5.  Effect of indoramin on human sperm motility.

Authors:  R B Verma; S M Abrams; P Turner
Journal:  Br J Clin Pharmacol       Date:  1983-01       Impact factor: 4.335

6.  A simple method to measure drug effects on human sperm motility.

Authors:  C Y Hong; D M Chaput de Saintonge; P Turner
Journal:  Br J Clin Pharmacol       Date:  1981-04       Impact factor: 4.335

7.  Propranolol as a novel, effective spermicide: preliminary findings.

Authors:  J Zipper; R G Wheeler; D M Potts; M Rivera
Journal:  Br Med J (Clin Res Ed)       Date:  1983-10-29

8.  Propranolol concentrations in plasma after insertion into the vagina.

Authors:  L G Patel; S J Warrington; R M Pearson
Journal:  Br Med J (Clin Res Ed)       Date:  1983-10-29

9.  Pharmacology of AH 5158; a drug which blocks both - and -adrenoceptors.

Authors:  J B Farmer; I Kennedy; G P Levy; R J Marshall
Journal:  Br J Pharmacol       Date:  1972-08       Impact factor: 8.739

10.  Studies on the mechanism of uncoupling by amine local anesthetics. Evidence for mitochondrial proton transport mediated by lipophilic ion pairs.

Authors:  K D Garlid; R A Nakashima
Journal:  J Biol Chem       Date:  1983-07-10       Impact factor: 5.157
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  2 in total

1.  Involvement of calcium in the caffeine stimulation of human sperm motility.

Authors:  C Y Hong; B N Chiang; P Wu; Y H Wei; J C Fong
Journal:  Br J Clin Pharmacol       Date:  1985-06       Impact factor: 4.335

2.  Calcium antagonists stimulate sperm motility in ejaculated human semen.

Authors:  C Y Hong; B N Chiang; J Ku; Y H Wei; J C Fong
Journal:  Br J Clin Pharmacol       Date:  1985-01       Impact factor: 4.335
  2 in total

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